Detalhe da pesquisa
1.
Preclinical safety assessment of toxicity and biodistribution of oncolytic virus HSV-1 expressing human PD-1 antibody in mice.
Regul Toxicol Pharmacol
; 132: 105166, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35405296
2.
Regulatory landscape of dietary supplements and herbal medicines from a global perspective.
Regul Toxicol Pharmacol
; 114: 104647, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32305367
3.
Quality, bioactivity study, and preclinical acute toxicity, safety pharmacology evaluation of PEGylated recombinant human endostatin (M2 ES).
J Biochem Mol Toxicol
; 33(3): e22257, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536793
4.
A case report of spontaneous staphylococcal meningitis in a cynomolgus monkey.
J Med Primatol
; 47(2): 132-135, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29399828
5.
A pre-clinical safety study of PEGylated recombinant human endostatin (M2ES) in Sprague Dawley rats.
Regul Toxicol Pharmacol
; 95: 190-197, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29580973
6.
The HepaRG cell line, a superior in vitro model to L-02, HepG2 and hiHeps cell lines for assessing drug-induced liver injury.
Cell Biol Toxicol
; 32(1): 37-59, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27027780
7.
Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb.
J Asian Nat Prod Res
; 18(9): 813-22, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27139982
8.
Hep-2 cell based indirect immunofluorescence assay for antinuclear antibodies as a potential diagnosis of drug-induced autoimmunity in nonclinical toxicity testing.
Regul Toxicol Pharmacol
; 71(2): 141-7, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25455225
9.
High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury.
Drug Metab Dispos
; 42(4): 744-50, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24464804
10.
Pre-clinical toxicokinetics and safety study of M2ES, a PEGylated recombinant human endostatin, in rhesus monkeys.
Regul Toxicol Pharmacol
; 69(3): 512-23, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24878240
11.
A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction.
Toxicology
; 505: 153829, 2024 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38740170
12.
Safety evaluation of PEGylated MNPs and p-PEGylated MNPs in SD rats.
Sci Rep
; 13(1): 21501, 2023 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38057444
13.
Tocilizumab treatment in neuromyelitis optica spectrum disorders: Updated meta-analysis of efficacy and safety.
Mult Scler Relat Disord
; 80: 105062, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37866020
14.
Targeting chemoattractant chemokine (C-C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders.
Front Immunol
; 14: 1144532, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37056770
15.
Corn oil as a vehicle in drug development exerts a dose-dependent effect on gene expression profiles in rat thymus.
J Appl Toxicol
; 32(10): 850-7, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22760963
16.
Market entry system considering the biosafety of nanomedical devices in China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol
; 14(6): e1821, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36416024
17.
Pre-clinical efficacy of CD20-targeted chimeric antigen receptor T cells for non-Hodgkin's lymphoma.
Discov Oncol
; 13(1): 122, 2022 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36352168
18.
Functional differences and similarities in activated peripheral blood mononuclear cells by lipopolysaccharide or phytohemagglutinin stimulation between human and cynomolgus monkeys.
Ann Transl Med
; 9(3): 257, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33708884
19.
Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity in RPTEC/TERT1 cells.
Toxicol Res (Camb)
; 9(2): 91-100, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32440340
20.
Author Correction: Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents.
Sci Rep
; 10(1): 17018, 2020 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33028942