RESUMO
The survival of 502 kidney grafts (458 first-grafts and 44 second-grafts) performed at Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, was analyzed in relation to the degree of HLA compatibility. The actuarial graft survival for first-transplants, at 1 and 5 years, was a follows: a) HLA-identical donor: 90 and 83%; b) one-haplotype identical donor: 68 and 54%; c) unrelated living donor: 61 and 37.5% and d) cadaver donor: 52.5 and 32%. These survival data are similar to those reported by other transplantation groups and confirm the important role of the HLA antigens in the outcome of renal transplantation.
Assuntos
Sobrevivência de Enxerto , Antígenos HLA/imunologia , Histocompatibilidade , Transplante de Rim , Análise Atuarial , Teste de Histocompatibilidade , Humanos , Doadores de TecidosRESUMO
A rare association of ankylosing spondylitis (AS) and systemic sclerosis (SSc) is reported in a Brazilian Mestizo patient presenting a human leucocyte antigen (HLA) genotype that included HLA SSc-susceptibility genes previously reported in different ethnic groups and HLA-B27 associated with AS. The underlying genetic background supporting the full expression of both SSc- and AS-susceptibility alleles and the pertinent literature are discussed.
Assuntos
Predisposição Genética para Doença , Antígeno HLA-B27/genética , Escleroderma Sistêmico/complicações , Escleroderma Sistêmico/genética , Espondilite Anquilosante/complicações , Espondilite Anquilosante/genética , Adulto , Genótipo , Antígeno HLA-B27/sangue , Humanos , Masculino , Escleroderma Sistêmico/imunologia , Espondilite Anquilosante/imunologiaRESUMO
This study investigates alloantisera containing antibodies directed against antigens which are expressed on alloactivated human T lymphocytes but are absent on resting T and B cells. Among 39 defined anti-HLA-DR sera from multiparous women we found six sera giving positive reactions (more than 25 percent cytotoxicity) on in vitro alloactivated T cells, though negative reactions with resting B or T cells from the donors of either the responding or stimulating cell populations used for alloactivation. Two such sera were submitted to absorption and elution studies. Absorption of these sera with activated T cells did not remove the anti-HLA-DR activity. Furthermore, the antibodies eluted from activated T cells did not react with B cells but were positive only on activated T cells. In addition, we absorbed the sera with B cells and observed that they remained positive on activated T cells. The positive reactions do not seem to be due to either the passive acquisition of antigens from the stimulating population or to low levels of HLA-specific antibodies. As one of the sera we studied intensively gave clear positive and negative reactions on a panel of activated T lymphocytes, we believe it may recognize an antigen of an allogeneic system expressed on alloactivated human T cells.
Assuntos
Antígenos de Superfície/imunologia , Isoanticorpos/imunologia , Isoantígenos/imunologia , Ativação Linfocitária , Linfócitos T/imunologia , Especificidade de Anticorpos , Feminino , Teste de Histocompatibilidade , HumanosRESUMO
A total of 977 White individuals living in five Brazilian cities, as well as 173 Black individuals from two of these cities have been studied in relation to HLA-A and HLA-B. Allele frequency similarities among these populations are much more impressive than dissimilarities, and the differences, considering putative ancestors, are not remarkable. This limited variability can be only partially explained in terms of racial admixture, estimates of the latter using different alleles in the various populations showing disparate results. Linkage disequilibrium values vary between groups, that for A1-B8 being the most consistent, independent of sample or race. But four other haplotypes observed to be in significant disequilibrium in Portugal showed the same pattern in at least one of the five Brazilian White samples.