Detalhe da pesquisa
1.
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
Immunity
; 55(6): 1032-1050.e14, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35704993
2.
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Nature
; 563(7731): 354-359, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30356218
3.
3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity.
Int J Mol Sci
; 25(1)2023 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38203650
4.
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization.
Eur J Med Chem
; 274: 116511, 2024 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38820854
5.
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.
J Med Chem
; 65(5): 3962-3977, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35195417
6.
Structural Basis of Human Dimeric α-Amino-ß-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025.
Front Mol Biosci
; 9: 834700, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35463964
7.
Innovations and Emerging Therapies to Combat Renal Cell Damage: NAD+ As a Drug Target.
Antioxid Redox Signal
; 35(17): 1449-1466, 2021 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33499758
8.
Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.
Anal Bioanal Chem
; 397(5): 1997-2011, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20496034
9.
Targeting the conformational transitions of MDM2 and MDMX: insights into key residues affecting p53 recognition.
Proteins
; 77(3): 524-35, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19507240
10.
Bulky 1,4-benzoxazine derivatives with antifungal activity.
Bioorg Med Chem
; 17(11): 3838-46, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19433362
11.
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.
Bioorg Med Chem
; 17(1): 242-50, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19042134
12.
α-Amino-ß-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis.
J Med Chem
; 61(3): 745-759, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29345930
13.
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
J Med Chem
; 60(6): 2344-2360, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28240897
14.
Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.
ChemMedChem
; 11(12): 1219-26, 2016 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26424664
15.
Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy.
Cancer Res
; 75(21): 4560-72, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26359458
16.
Probing the Binding Site of Bile Acids in TGR5.
ACS Med Chem Lett
; 4(12): 1158-62, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900622
17.
Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon?
Expert Opin Ther Pat
; 21(3): 287-94, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21342053
18.
Computational studies for the elucidation of the enantiomer elution order of amino acids in chiral ligand-exchange chromatography.
J Chromatogr A
; 1217(48): 7523-7, 2010 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20977972
19.
Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition.
J Chem Inf Model
; 48(10): 1999-2009, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18826207
20.
Oxime and oxime ether derivatives of 1,4-benzothiazine related to oxiconazole.
ChemMedChem
; 2(8): 1208-13, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17541993