Detalhe da pesquisa
1.
Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.
N Engl J Med
; 388(24): 2253-2261, 2023 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37314706
2.
Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia.
Blood
; 139(6): 859-875, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34662393
3.
Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells.
J Biol Chem
; 295(17): 5717-5736, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184360
4.
Biologically inactive leptin and early-onset extreme obesity.
N Engl J Med
; 372(1): 48-54, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25551525
5.
The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.
J Biol Chem
; 291(42): 22136-22148, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27542411
6.
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
Mol Cell
; 34(2): 223-33, 2009 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19394299
7.
Rac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling.
J Biol Chem
; 290(28): 17056-72, 2015 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25903139
8.
C2-streptavidin mediates the delivery of biotin-conjugated tumor suppressor protein p53 into tumor cells.
Bioconjug Chem
; 24(4): 595-603, 2013 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23506195
9.
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
EMBO Mol Med
; 14(3): e14901, 2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35170849
10.
Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2.
J Biol Chem
; 285(6): 3905-3915, 2010 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20007712
11.
Protein-protein-interactions in a multiplexed, miniaturized format a functional analysis of Rho GTPase activation and inhibition.
Proteomics
; 10(8): 1716-20, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20127689
12.
Bead-based protein-protein interaction assays for the analysis of Rho GTPase signaling.
J Mol Recognit
; 23(6): 543-50, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-21031432
13.
Constitutive serum response factor activation by the viral chemokine receptor homologue pUS28 is differentially regulated by Galpha(q/11) and Galpha(16).
Cell Signal
; 20(8): 1528-37, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18534820
14.
In vitro reconstitution of activation of PLCepsilon by Ras and Rho GTPases.
Methods Mol Biol
; 462: 379-89, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19160682
15.
cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs.
Naunyn Schmiedebergs Arch Pharmacol
; 392(8): 887-911, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31101932
16.
Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations.
J Endocr Soc
; 3(1): 27-41, 2019 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30560226
17.
Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors.
Blood Adv
; 7(19): 5698-5702, 2023 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36661329
18.
Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder.
Oncotarget
; 9(76): 34357-34378, 2018 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344948
19.
SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells.
Circ Res
; 96(7): 784-91, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15761195
20.
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Cell Signal
; 18(8): 1156-68, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16257181