Detalhe da pesquisa
1.
Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review.
Pharmacol Res
; 177: 106076, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35074524
2.
Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers.
Int J Mol Sci
; 22(23)2021 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34884436
3.
Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.
Biochem Biophys Res Commun
; 491(3): 681-686, 2017 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28756225
4.
Corrigendum to "Future directions for the discovery of natural product-derived immunomodulating drugs: An IUPHAR positional review" [Pharmacol. Res. 177 (2022) 106076].
Pharmacol Res
; 180: 106207, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35428550
5.
Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.
Proc Natl Acad Sci U S A
; 107(28): 12634-9, 2010 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20616035
6.
1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.
J Biol Chem
; 286(51): 43951-43958, 2011 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22020937
7.
Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
J Pharmacol Exp Ther
; 343(3): 617-27, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22935731
8.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 22(14): 4528-31, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22727637
9.
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.
Bioorg Med Chem Lett
; 22(14): 4750-5, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22695126
10.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Bioorg Med Chem Lett
; 22(9): 3208-12, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22465635
11.
Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML.
Blood
; 113(17): 4052-62, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19144991
12.
Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
Bioorg Med Chem Lett
; 21(18): 5620-4, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21778056
13.
G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.
J Clin Invest
; 117(10): 3107-17, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17823654
14.
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
J Med Chem
; 51(5): 1231-41, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260617
15.
In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor.
Leuk Res
; 32(7): 1091-100, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160102
16.
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2691-5, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18362070
17.
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors.
Bioorg Med Chem Lett
; 18(1): 386-90, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18023347
18.
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
J Med Chem
; 50(7): 1584-97, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17343372
19.
Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo.
Int J Oncol
; 31(6): 1391-402, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17982666
20.
Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors.
Mol Cancer Ther
; 5(4): 1007-13, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648572