Detalhe da pesquisa
1.
DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice.
PLoS Pathog
; 17(11): e1010038, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34767618
2.
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes.
Nucleic Acids Res
; 49(3): 1436-1454, 2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33450001
3.
PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.
Mol Cell
; 52(4): 554-65, 2013 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24267450
4.
A post-transcriptional respiratome regulon in trypanosomes.
Nucleic Acids Res
; 47(13): 7063-7077, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31127277
5.
Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei.
PLoS Pathog
; 13(3): e1006279, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334017
6.
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.
Proc Natl Acad Sci U S A
; 113(26): 7225-30, 2016 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226299
7.
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Nature
; 482(7384): 232-6, 2012 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22278056
8.
High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes.
BMC Genomics
; 17(1): 806, 2016 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27756224
9.
Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome.
Nucleic Acids Res
; 42(20): 12600-13, 2014 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25300492
10.
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes.
PLoS Pathog
; 9(3): e1003260, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23555264
11.
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
Proc Natl Acad Sci U S A
; 109(27): 10996-1001, 2012 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22711816
12.
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.
Genome Res
; 21(6): 915-24, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21363968
13.
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
J Antimicrob Chemother
; 69(3): 651-63, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24235095
14.
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.
Cell Microbiol
; 15(12): 1984-93, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24047558
15.
Microhomology-mediated deletion and gene conversion in African trypanosomes.
Nucleic Acids Res
; 39(4): 1372-80, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20965968
16.
Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome.
PLoS Negl Trop Dis
; 17(2): e0011093, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36780870
17.
Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei.
mBio
; 13(2): e0384721, 2022 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35229632
18.
VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei.
Front Cell Dev Biol
; 10: 851475, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35450294
19.
SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis.
EBioMedicine
; 85: 104308, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36374773
20.
Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.
Nat Microbiol
; 6(3): 289-300, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33432154