Detalhe da pesquisa
1.
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Cell
; 185(13): 2213-2233.e25, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35750033
2.
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Cell
; 184(17): 4547-4563.e17, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314701
3.
A Tale of Two Genes: Microglial Apoe and Trem2.
Immunity
; 47(3): 398-400, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930654
4.
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.
Ann Neurol
; 95(4): 625-634, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38180638
5.
Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.
Proc Natl Acad Sci U S A
; 119(34): e2108870119, 2022 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35969759
6.
Novel avenues of tau research.
Alzheimers Dement
; 20(3): 2240-2261, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170841
7.
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden.
Alzheimers Dement
; 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38666355
8.
Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-ß monoclonal antibodies in dominantly inherited Alzheimer's disease.
Eur J Nucl Med Mol Imaging
; 50(9): 2669-2682, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017737
9.
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.
Psychol Med
; 53(4): 1196-1204, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34231451
10.
Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology.
Brain
; 145(10): 3594-3607, 2022 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35580594
11.
Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals.
Alzheimers Dement
; 19(12): 5333-5342, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37177856
12.
Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred.
Alzheimers Dement
; 19(9): 3835-3847, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36951251
13.
APOE and immunity: Research highlights.
Alzheimers Dement
; 19(6): 2677-2696, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975090
14.
APOE4 confers transcriptomic and functional alterations to primary mouse microglia.
Neurobiol Dis
; 164: 105615, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35031484
15.
A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data.
Am J Hum Genet
; 105(4): 822-835, 2019 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585107
16.
Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome.
Ann Neurol
; 89(1): 54-65, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32996171
17.
Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD.
Acta Neuropathol
; 143(2): 225-243, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34874463
18.
Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders.
Mol Psychiatry
; 26(4): 1142-1151, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31477794
19.
Current directions in tau research: Highlights from Tau 2020.
Alzheimers Dement
; 18(5): 988-1007, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581500
20.
Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response.
Neurobiol Dis
; 148: 105217, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33301878