Detalhe da pesquisa
1.
Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.
Nucleic Acids Res
; 46(2): 886-896, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29156002
2.
In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells.
BMC Cancer
; 19(1): 1251, 2019 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31881855
3.
The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor ß Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression.
J Am Chem Soc
; 139(22): 7456-7475, 2017 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28471683
4.
The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.
J Biol Chem
; 290(3): 1623-38, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25477506
5.
A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters.
J Am Chem Soc
; 138(41): 13673-13692, 2016 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27643954
6.
The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.
J Am Chem Soc
; 136(11): 4161-71, 2014 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24559410
7.
Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma.
Biomedicines
; 12(2)2024 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38398008
8.
Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.
Top Curr Chem
; 330: 1-21, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-22752577
9.
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.
Bioorg Med Chem Lett
; 23(2): 528-31, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23237838
10.
Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.
J Biol Chem
; 286(47): 41018-27, 2011 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21956115
11.
Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events.
J Am Chem Soc
; 134(11): 5157-64, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22372563
12.
Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.
Invest New Drugs
; 30(5): 1865-77, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21931968
13.
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.
Bioorg Med Chem Lett
; 22(10): 3567-70, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22516282
14.
Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1.
Antiviral Res
; 208: 105432, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36228762
15.
Correction to "The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure".
J Am Chem Soc
; 138(35): 11408, 2016 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571358
16.
In Silico Targeting of the Long Noncoding RNA MALAT1.
ACS Med Chem Lett
; 12(6): 915-921, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141069
17.
Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Sci Transl Med
; 13(619): eabh1314, 2021 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34757807
18.
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.
Bioorg Med Chem
; 18(1): 292-304, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19962319
19.
Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.
Nucleic Acids Res
; 36(14): 4598-608, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614607
20.
Erratum: Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.
Oncotarget
; 11(26): 2586, 2020 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32655842