Detalhe da pesquisa
1.
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Proc Natl Acad Sci U S A
; 118(15)2021 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33833060
2.
Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid.
Alzheimers Dement
; 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38713744
3.
P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.
Brain Behav Immun
; 114: 414-429, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37716378
4.
Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.
Proc Natl Acad Sci U S A
; 117(31): 18591-18599, 2020 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690681
5.
Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes.
Mol Ther
; 29(2): 859-872, 2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33128896
6.
Intracerebral but Not Peripheral Infection of Live Porphyromonas gingivalis Exacerbates Alzheimer's Disease Like Amyloid Pathology in APP-TgCRND8 Mice.
Int J Mol Sci
; 23(6)2022 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35328748
7.
Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy.
Hum Mol Genet
; 28(19): 3255-3269, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31261380
8.
Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
Acta Neuropathol
; 141(3): 359-381, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496840
9.
Precision therapeutic targets for COVID-19.
Virol J
; 18(1): 66, 2021 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33781287
10.
Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease.
Alzheimers Dement
; 17(6): 984-1004, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33480174
11.
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
J Biol Chem
; 294(29): 11276-11285, 2019 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167792
12.
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Mol Psychiatry
; 24(9): 1383-1397, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30283031
13.
Scientific Advising and Reviewing: On strengthening the bond between the Alzheimer's Association and the scientific community.
Alzheimers Dement
; 16(7): 1095-1098, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32426924
14.
Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies.
J Biol Chem
; 293(7): 2408-2421, 2018 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29259137
15.
Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis.
Neuroimage
; 202: 116138, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31472250
16.
MAPT mutations, tauopathy, and mechanisms of neurodegeneration.
Lab Invest
; 99(7): 912-928, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30742061
17.
The stress response neuropeptide CRF increases amyloid-ß production by regulating γ-secretase activity.
EMBO J
; 34(12): 1674-86, 2015 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25964433
18.
Holdase activity of secreted Hsp70 masks amyloid-ß42 neurotoxicity in Drosophila.
Proc Natl Acad Sci U S A
; 113(35): E5212-21, 2016 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27531960
19.
Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration.
Neurobiol Dis
; 110: 133-141, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29196213
20.
Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration.
Neurobiol Dis
; 120: 98-106, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30195075