Detalhe da pesquisa
1.
Structural basis of antifolate recognition and transport by PCFT.
Nature
; 595(7865): 130-134, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34040256
2.
Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.
Proc Natl Acad Sci U S A
; 116(35): 17531-17540, 2019 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31405972
3.
A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation.
J Biol Chem
; 295(46): 15650-15661, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32893190
4.
Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation.
J Biol Chem
; 294(18): 7245-7258, 2019 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858177
5.
Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1).
Am J Physiol Cell Physiol
; 314(3): C289-C296, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29167151
6.
Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.
Mol Pharmacol
; 93(3): 208-215, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29326243
7.
A conversation with Susan Band Horwitz.
Annu Rev Pharmacol Toxicol
; 55: 1-9, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25562642
8.
The intestinal absorption of folates.
Annu Rev Physiol
; 76: 251-74, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24512081
9.
Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation.
Am J Physiol Cell Physiol
; 312(4): C517-C526, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28122733
10.
Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.
J Biol Chem
; 291(15): 8162-72, 2016 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26884338
11.
Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.
Biochim Biophys Acta Biomembr
; 1859(11): 2193-2202, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28802835
12.
Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier.
Mol Pharm
; 14(11): 3848-3858, 2017 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28885847
13.
Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.
Am J Physiol Cell Physiol
; 311(1): C150-7, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27251438
14.
Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).
Am J Physiol Cell Physiol
; 308(8): C631-41, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25608532
15.
Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression.
Mol Pharmacol
; 85(2): 310-21, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24249723
16.
Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.
Am J Physiol Cell Physiol
; 304(12): C1159-67, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23552283
17.
Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.
Mol Pharmacol
; 84(1): 95-103, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23609145
18.
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
Am J Physiol Cell Physiol
; 303(6): C673-81, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22785121
19.
A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.
Am J Physiol Cell Physiol
; 302(9): C1405-12, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22345511
20.
Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate.
Mol Pharmacol
; 82(2): 209-16, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22554803