A method for AI assisted human interpretation of neonatal EEG.

The study proposes a novel method to empower healthcare professionals to interact and leverage AI decision support in an intuitive manner using auditory senses. The method's suitability is assessed through acoustic detection of the presence of neonatal seizures in electroencephalography (EEG). Neurophysiologists use EEG recordings to identify seizures visually. However, neurophysiological expertise is expensive and not available 24/7, even in tertiary hospitals. Other neonatal and pediatric medical professionals (nurses, doctors, etc.) can make erroneous interpretations of highly complex EEG signals. While artificial intelligence (AI) has been widely used to provide objective decision support for EEG analysis, AI decisions are not always explainable. This work developed a solution to combine AI algorithms with a human-centric intuitive EEG interpretation method. Specifically, EEG is converted to sound using an AI-driven attention mechanism. The perceptual characteristics of seizure events can be heard using this method, and an hour of EEG can be analysed in five seconds. A survey that has been conducted among targeted end-users on a publicly available dataset has demonstrated that not only does it drastically reduce the burden of reviewing the EEG data, but also the obtained accuracy is on par with experienced neurophysiologists trained to interpret neonatal EEG. It is also shown that the proposed communion of a medical professional and AI outperforms AI alone by empowering the human with little or no experience to leverage AI attention mechanisms to enhance the perceptual characteristics of seizure events.

Automatic segmentation for neonatal phonocardiogram.

This work addresses the automatic segmentation of neonatal phonocardiogram (PCG) to be used in the artificial intelligence-assisted diagnosis of abnormal heart sounds. The proposed novel algorithm has a single free parameter - the maximum heart rate. The algorithm is compared with the baseline algorithm, which was developed for adult PCG segmentation. When evaluated on a large clinical dataset of neonatal PCG with a total duration of over 7h, an F1 score of 0.94 is achieved. The main features relevant for the segmentation of neonatal PCG are identified and discussed. The algorithm is able to increase the number of cardiac cycles by a factor of 5 compared to manual segmentation, potentially allowing to improve the performance of heart abnormality detection algorithms.

An EEG analysis framework through AI and sonification on low power IoT edge devices.

This study explores the feasibility of implementation of an analysis framework of neonatal EEG, including ML, sonification and intuitive visualization, on a low power IoT edge device. Electroencephalography (EEG) analysis is a very important tool to detect brain disorders. Neonatal seizure detection is a known, challenging problem. Under-resourced communities across the globe are particularly affected by the cost associated with EEG analysis and interpretation. Machine learning (ML) techniques have been successfully utilized to automate seizure detection in neonatal EEG, in order to assist a healthcare professional in visual analysis. Several usage scenarios are reviewed in this study. It is shown that both sonification and ML can be efficiently implemented on low-power edge platforms without any loss of accuracy. The developed platform can be easily expanded to address EEG analysis applications in neonatal and adult population.

A Framework for AI-Assisted Detection of Patent Ductus Arteriosus from Neonatal Phonocardiogram.

The current diagnosis of Congenital Heart Disease (CHD) in neonates relies on echocardiography. Its limited availability requires alternative screening procedures to prioritise newborns awaiting ultrasound. The routine screening for CHD is performed using a multidimensional clinical examination including (but not limited to) auscultation and pulse oximetry. While auscultation might be subjective with some heart abnormalities not always audible it increases the ability to detect heart defects. This work aims at developing an objective clinical decision support tool based on machine learning (ML) to facilitate differentiation of sounds with signatures of Patent Ductus Arteriosus (PDA)/CHDs, in clinical settings. The heart sounds are pre-processed and segmented, followed by feature extraction. The features are fed into a boosted decision tree classifier to estimate the probability of PDA or CHDs. Several mechanisms to combine information from different auscultation points, as well as consecutive sound cycles, are presented. The system is evaluated on a large clinical dataset of heart sounds from 265 term and late-preterm newborns recorded within the first six days of life. The developed system reaches an area under the curve (AUC) of 78% at detecting CHD and 77% at detecting PDA. The obtained results for PDA detection compare favourably with the level of accuracy achieved by an experienced neonatologist when assessed on the same cohort.