Detalhe da pesquisa
1.
Defining the mechanism of galectin-3-mediated TGF-ß1 activation and its role in lung fibrosis.
J Biol Chem
; : 107300, 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641066
2.
Conformational pathology of the serpins: themes, variations, and therapeutic strategies.
Annu Rev Biochem
; 78: 147-76, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19245336
3.
Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID-19 Study.
Am J Respir Crit Care Med
; 207(6): 693-703, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36457159
4.
Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.
Gut
; 71(2): 415-423, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33632708
5.
Real-world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha-1-antitrypsin deficiency.
Hum Mutat
; 39(9): 1203-1213, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29882371
6.
Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.
Hum Mol Genet
; 25(4): 642-50, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26647313
7.
hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.
J Hepatol
; 69(4): 851-860, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29879455
8.
Surfactant protein C mutations and familial pulmonary fibrosis: stuck in a loop on the scenic route.
Eur Respir J
; 59(1)2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35086844
9.
Rheumatologists have an important role in the management of interstitial lung disease (ILD): a cross-speciality, multi-centre, UK perspective.
Rheumatology (Oxford)
; 61(5): 1748-1751, 2022 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104331
10.
Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.
Am J Respir Cell Mol Biol
; 54(1): 71-80, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26091018
11.
Update on alpha-1 antitrypsin deficiency: New therapies.
J Hepatol
; 65(2): 413-24, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27034252
12.
Familial hypereosinophilia associated with eosinophilic gastrointestinal symptoms in individuals with a missense mutation in CKLF-like MARVEL transmembrane domain containing 3.
Clin Exp Allergy
; 51(11): 1501-1504, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34048099
13.
Defining the mechanism of polymerization in the serpinopathies.
Proc Natl Acad Sci U S A
; 107(40): 17146-51, 2010 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855577
14.
Multi-center evaluation of baseline neutrophil-to-lymphocyte (NLR) ratio as an independent predictor of mortality and clinical risk stratifier in idiopathic pulmonary fibrosis.
EClinicalMedicine
; 55: 101758, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36483266
15.
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study.
Lancet Respir Med
; 11(1): 87-96, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36075242
16.
A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.
Hepatology
; 52(3): 1078-88, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20583215
17.
Therapeutic target-site variability in α1-antitrypsin characterized at high resolution.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 12): 1492-7, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22139150
18.
Use of peripheral neutrophil to lymphocyte ratio and peripheral monocyte levels to predict survival in fibrotic hypersensitivity pneumonitis (fHP): a multicentre retrospective cohort study.
BMJ Open Respir Res
; 8(1)2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34794958
19.
The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-ß Dependent: A Proposed Anti-inflammatory Role in Airway Disease.
Front Nutr
; 8: 667203, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458299
20.
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID).
BMJ Open Respir Res
; 8(1)2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34556492