Detalhe da pesquisa
1.
The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary.
Drug Metab Dispos
; 52(3): 198-209, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123948
2.
Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome.
Drug Metab Dispos
; 45(5): 501-511, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28254951
3.
Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.
J Pharmacol Exp Ther
; 351(2): 259-69, 2014 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25125580
4.
Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants.
Clin Transl Sci
; 17(2): e13687, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38362827
5.
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Xenobiotica
; 43(11): 963-72, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23631744
6.
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
ACS Med Chem Lett
; 14(10): 1427-1433, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849537
7.
A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications.
AAPS J
; 25(6): 102, 2023 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37891356
8.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Adv Biol (Weinh)
; : e2300131, 2023 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37814378
9.
Application of PBPK modelling in drug discovery and development at Pfizer.
Xenobiotica
; 42(1): 94-106, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22035569
10.
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
J Med Chem
; 65(22): 15000-15013, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36322383
11.
Quantitative prediction of breast cancer resistant protein mediated drug-drug interactions using physiologically-based pharmacokinetic modeling.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 1018-1031, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164937
12.
Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions.
Lab Chip
; 20(19): 3653, 2020 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32756648
13.
A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions.
Lab Chip
; 19(9): 1556-1566, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30855604
14.
Correction: A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications.
AAPS J
; 26(1): 2, 2023 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37985630
15.
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
ACS Med Chem Lett
; 9(2): 125-130, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456800
16.
Towards in vitro models for reducing or replacing the use of animals in drug testing.
Nat Biomed Eng
; 2023 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151640
17.
A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679.
Eur J Pharm Sci
; 109S: S161-S167, 2017 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28603038
18.
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
J Med Chem
; 59(3): 1165-75, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26734723
19.
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Sci Rep
; 5: 17391, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26620127
20.
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.
J Med Chem
; 58(18): 7164-72, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26258602