Detalhe da pesquisa
1.
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA.
J Virol
; 95(18): e0057421, 2021 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34191584
2.
Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer.
J Med Chem
; 67(2): 1421-1446, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38190324
3.
Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161.
Viruses
; 16(3)2024 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38543689
4.
A G protein-biased ligand at the µ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.
J Pharmacol Exp Ther
; 344(3): 708-17, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23300227
5.
Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1.
Tetrahedron
; 65(33): 6489-6509, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20640040
6.
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element.
Antiviral Res
; 149: 191-201, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29133129
7.
Spongistatin synthetic studies. evolution of a scalable synthesis for the EF fragment of (+)-Spongistatin 1 exploiting a Petasis-Ferrier union/rearrangement tactic.
Org Lett
; 6(20): 3637-40, 2004 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15387567
8.
Structure-activity relationships and discovery of a G protein biased µ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.
J Med Chem
; 56(20): 8019-31, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24063433
9.
Synthetic studies toward (-)-FR901483 using a conjugate allylation to install the C-1 quaternary carbon.
J Org Chem
; 71(25): 9393-402, 2006 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17137366