Detalhe da pesquisa
1.
The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model.
J Neurosci
; 42(9): 1820-1844, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34992132
2.
Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation.
J Neuroinflammation
; 19(1): 3, 2022 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34983562
3.
Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.
Glycobiology
; 31(8): 988-1004, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33909046
4.
A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice.
Development
; 145(1)2018 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317443
5.
Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.
J Biol Chem
; 290(42): 25756-65, 2015 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296882
6.
Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.
Hum Mol Genet
; 23(14): 3865-74, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24599401
7.
Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.
Neurobiol Dis
; 82: 22-31, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26019056
8.
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Proc Natl Acad Sci U S A
; 108(10): 4129-34, 2011 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21325052
9.
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.
Proc Natl Acad Sci U S A
; 108(45): E1070-9, 2011 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22025691
10.
The choroid plexus maintains ventricle volume and adult subventricular zone neuroblast pool, which facilitates post-stroke neurogenesis.
bioRxiv
; 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38328050
11.
Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.
Hum Mol Genet
; 20(23): 4597-604, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21890496
12.
Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.
Hum Mol Genet
; 20(7): 1290-305, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21212099
13.
Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice.
Behav Genet
; 43(1): 51-9, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23229624
14.
Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus.
Fluids Barriers CNS
; 20(1): 42, 2023 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37296418
15.
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.
Nat Neurosci
; 25(4): 458-473, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35379995
16.
A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Hum Mol Genet
; 18(13): 2378-87, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19357198
17.
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice.
J Neurosurg Pediatr
; : 1-8, 2020 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32032950
18.
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.
Nat Med
; 26(11): 1754-1765, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33077954
19.
Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development.
Mol Cell Neurosci
; 38(2): 203-12, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18403215
20.
Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam.
J Neurosurg
; 132(3): 945-958, 2019 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30738385