Detalhe da pesquisa
1.
The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage.
Nucleic Acids Res
; 52(7): 3740-3760, 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38321962
2.
Correction: Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.
PLoS Genet
; 19(12): e1011094, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38117757
3.
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency.
Drug Resist Updat
; 67: 100932, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706533
4.
Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing.
EMBO J
; 38(16): e101284, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31294866
5.
Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices.
Nucleic Acids Res
; 49(13): 7457-7475, 2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34165573
6.
Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.
Nucleic Acids Res
; 48(21): 12188-12203, 2020 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33166398
7.
Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells.
Nucleic Acids Res
; 45(3): 1270-1280, 2017 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28180309
8.
Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.
PLoS Genet
; 12(1): e1005792, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26765540
9.
DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
Proc Natl Acad Sci U S A
; 113(30): E4311-9, 2016 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27407148
10.
Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model.
Genet Mol Biol
; 43(1 suppl 1): e20190070, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31930278
11.
Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.
Proc Natl Acad Sci U S A
; 112(48): E6624-33, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627254
12.
UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability.
Nucleic Acids Res
; 41(14): 6942-51, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23723248
13.
Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.
Proc Natl Acad Sci U S A
; 109(19): 7344-9, 2012 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22529391
14.
A mitotic stopwatch determines cell fate.
Science
; 383(6690): 1414-1415, 2024 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38547295
15.
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells.
Elife
; 122023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37073955
16.
Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability.
Sci Adv
; 9(15): eade7997, 2023 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37058556
17.
Structural Chromosome Instability: Types, Origins, Consequences, and Therapeutic Opportunities.
Cancers (Basel)
; 13(12)2021 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34205328
18.
PARP Activity Fine-tunes the DNA Replication Choreography of Chk1-depleted Cells.
J Mol Biol
; 433(10): 166949, 2021 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744317
19.
p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.
Mol Cell Biol
; 27(4): 1309-20, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17158927
20.
Suppression of cancer growth by nonviral gene therapy based on a novel reactive oxygen species-responsive promoter.
Mol Ther
; 17(8): 1355-64, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19436270