In situ synthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity.

It is difficult for the scientific community to develop a nonenzymatic sensing platform for extremely sensitive and selective detection of specific biomolecules, antibiotics, food adulterants, heavy metals, etc. One of the most significant chemotherapy drugs, 5-fluorouracil (5-Fu), which is used to treat solid malignancies, has a fluorine atom in the fifth position of the uracil molecule. Recognizing the secure and effective dosing of drugs for chemotherapy continues to be a critical concern in cancer disease management. The maintenance of the optimal 5-Fu concentration is dependent on the presence of 5-Fu in biofluids. Herein we reported a conducting polymer encapsulated 2D material, PTh/h-BN for the efficient electrochemical detection of anticancer drug 5-Fu. Furthermore, the synthesized PTh/h-BN nanocomposite was confirmed by the High-Resolution Transmission Electron Microscope (HR-TEM), High-Resolution Scanning Electron Microscope (HR-SEM), X-ray diffraction (XRD), and Fourier-Transform Infrared Spectroscopy (FT-IR). The electrical resistance of PTh/h-BN modified GCE and its sensing performance towards 5-Fu were tested using Electrochemical Impedance Spectroscopy (EIS) and Cyclic Voltammetry (CV) studies respectively. The analytical performance of our proposed catalyst was tested using Differential Pulse Voltammetry (DPV), and the amperometry (i-t curve) method. From the results, our proposed PTh/h-BN nanocomposite-modified GCE shows enhanced sensing performance due to higher redox peak currents, large active surface area, and high electrical conductivity. Moreover, the nanohybrid shows enhanced sensing performances with quick response time, wide linear range, the lowest limit of detection, high sensitivity, and high selectivity in the presence of various interferents. Finally, the practical applicability of the proposed sensor was tested with real-world samples with very good recovery percentages.

Crystal plane-integrated strontium oxide/hexagonal boron nitride nanohybrids for rapid electrochemical sensing of anticancer drugs in human blood serum samples.

In this work, the crystal plane of strontium oxide (SrO) nanorods was integrated into hexagonal-boron nitride (h-BN) nanosheets to form 1D-2D (SrO/h-BN) composite were utilized for the electrochemical detection of the chemotherapeutic drug 5-fluorouracil (5-Fu). 5-Fu is a clinically proven and the third most frequently applied chemotherapeutic drug for treating solid tumours, such as colorectal, stomach, cutaneous and breast malignancies. Its overdoses lead to toxic metabolite accumulation that has serious adverse consequences on humans, including neurotoxicity, death and the induction of morbidity. Therefore, to improve the chemotherapy and predict the potential adverse effects of 5-Fu residues in the human body, susceptible and quick analytical methods for detecting 5-Fu in human body fluids (blood serum/plasma and urine) are needed. The effective interaction of the synthesized SrO/h-BN composite shows increased efficiency for the electrochemical detection of 5-Fu with good selectivity. Notably, a simple sonochemical method achieved a synergistic interaction between the (100) plane of SrO and the (002) plane of h-BN. Various analytical and spectroscopic techniques were used to characterize the SrO/h-BN nanocomposite, which provided useful insights into the composition and properties of the composite material. The crystalline, structural and chemical characteristics of the as-synthesized material were characterized by XRD, Raman spectroscopy, HR-TEM, XPS and HR-SEM. Furthermore, the proposed electrode's electrochemical sensing capability was analysed using CV, EIS, DPV and i-t curve methods. Numerous active sites created on a modified electrode enhanced the mass transport and electron transfer rate, thereby increasing the electrochemical activity towards the 5-Fu detection. Consequently, under optimized conditions, the SrO/h-BN/GCE exhibited remarkable selectivity, durability, low detection limit (0.003 µM) and wide linear range (0.02-56 µM) for 5-Fu. Finally, the successful application of this sensor for 5-Fu detection in biological samples was successfully tested with high recovery percentages.

Current advancements and prospects of enzymatic and non-enzymatic electrochemical glucose sensors.

This review discusses the most current developments and future perspectives in enzymatic and non-enzymatic glucose sensors, which have notably evolved over the preceding quadrennial period. Furthermore, a thorough exploration encompassed the sensor's intricate fabrication processes, the diverse range of materials employed, the underlying principles of detection, and an in-depth assessment of the sensors' efficacy in detecting glucose levels within essential bodily fluids such as human blood serums, urine, saliva, and interstitial fluids. It is worth noting that the accurate quantification of glucose concentrations within human blood has been effectively achieved by utilizing classical enzymatic sensors harmoniously integrated with optical and electrochemical transduction mechanisms. Monitoring glucose levels in various mediums has attracted exceptional attention from industrial to academic researchers for diabetes management, food quality control, clinical medicine, and bioprocess inspection. There has been an enormous demand for the creation of novel glucose sensors over the past ten years. Research has primarily concentrated on succeeding biocompatible and enhanced sensing abilities related to the present technologies, offering innovative avenues for more effective glucose sensors. Recent developments in wearable optical and electrochemical sensors with low cost, high stability, point-of-care testing, and online tracking of glucose concentration levels in biological fluids can aid in managing and controlling diabetes globally. New nanomaterials and biomolecules that can be used in electrochemical sensor systems to identify glucose concentration levels are developed thanks to advances in nanoscience and nanotechnology. Both enzymatic and non-enzymatic glucose electrochemical sensors have garnered much interest recently and have made significant strides in detecting glucose levels. In this review, we summarise several categories of non-enzymatic glucose sensor materials, including composites, non-precious transition metals and their metal oxides, hydroxides, precious metals and their alloys, carbon-based materials, conducting polymers, metal-organic framework (MOF)-based electrocatalysts, and wearable device-based glucose sensors deeply.