Detalhe da pesquisa
1.
Machine learning classifiers aid virtual screening for efficient design of mini-protein therapeutics.
Bioorg Med Chem Lett
; 38: 127852, 2021 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33609660
2.
Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms.
J Biol Chem
; 294(1): 89-100, 2019 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30409909
3.
Phylogenetic spread of sequence data affects fitness of consensus enzymes: Insights from triosephosphate isomerase.
Proteins
; 88(2): 274-283, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31407418
4.
Two-domain aminopeptidase of M1 family: Structural features for substrate binding and gating in absence of C-terminal domain.
J Struct Biol
; 208(1): 51-60, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31351924
5.
Catalytic triad heterogeneity in S51 peptidase family: Structural basis for functional variability.
Proteins
; 87(8): 679-692, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30968972
6.
Structures and activities of widely conserved small prokaryotic aminopeptidases-P clarify classification of M24B peptidases.
Proteins
; 87(3): 212-225, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536999
7.
Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
J Biol Chem
; 292(24): 10035-10047, 2017 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28476889
8.
Phylogenetic spread of sequence data affects fitness of SOD1 consensus enzymes: Insights from sequence statistics and structural analyses.
Proteins
; 86(6): 609-620, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29490429
9.
Crystal structure of a novel prolidase from Deinococcus radiodurans identifies new subfamily of bacterial prolidases.
Proteins
; 85(12): 2239-2251, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28929533
10.
Active site gate of M32 carboxypeptidases illuminated by crystal structure and molecular dynamics simulations.
Biochim Biophys Acta Proteins Proteom
; 1865(11 Pt A): 1406-1415, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844748
11.
Crystal structure and biochemical investigations reveal novel mode of substrate selectivity and illuminate substrate inhibition and allostericity in a subfamily of Xaa-Pro dipeptidases.
Biochim Biophys Acta Proteins Proteom
; 1865(2): 153-164, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27816563
12.
Gating role of His 72 in TmPurL enzyme uncovered by structural analyses and molecular dynamics simulations.
Bioorg Med Chem Lett
; 26(23): 5644-5649, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27818108
13.
Evolutionary conservation of protein dynamics: insights from all-atom molecular dynamics simulations of 'peptidase' domain of Spt16.
J Biomol Struct Dyn
; 41(4): 1445-1457, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34971347
14.
Crystal structure of XCC3289 from Xanthomonas campestris: homology with the N-terminal substrate-binding domain of Lon peptidase.
Acta Crystallogr F Struct Biol Commun
; 76(Pt 10): 488-494, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33006577
15.
Structural basis for the unusual substrate specificity of unique two-domain M1 metallopeptidase.
Int J Biol Macromol
; 147: 304-313, 2020 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31923495
16.
Crystal structures and biochemical analyses of intermediate cleavage peptidase: role of dynamics in enzymatic function.
FEBS Lett
; 593(4): 443-454, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30582634
17.
Structure of Asp-bound peptidase E from Salmonella enterica: Active site at dimer interface illuminates Asp recognition.
FEBS Lett
; 592(19): 3346-3354, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30194851
18.
Crystallization and preliminary X-ray crystallographic analysis of an artificial molten-globular-like triosephosphate isomerase protein of mixed phylogenetic origin.
Acta Crystallogr F Struct Biol Commun
; 70(Pt 11): 1521-5, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25372821
19.
Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis.
PLoS One
; 8(11): e77781, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24223728