Detalhe da pesquisa
1.
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-ß.
Nature
; 485(7400): 651-5, 2012 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22660329
2.
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Biol Chem
; 397(1): 45-55, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26351917
3.
Glutaminyl cyclases as novel targets for the treatment of septic arthritis.
J Infect Dis
; 207(5): 768-77, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23204180
4.
Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration.
BMC Neurosci
; 14: 108, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24083638
5.
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aß is induced by pyroglutamate-Aß formation.
J Neurosci
; 31(36): 12790-801, 2011 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21900558
6.
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
J Biol Chem
; 286(6): 4454-60, 2011 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21148560
7.
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
J Biol Chem
; 286(16): 14199-208, 2011 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21330373
8.
Optimizing the composition of a synthetic cellulosome complex for the hydrolysis of softwood pulp: identification of the enzymatic core functions and biochemical complex characterization.
Biotechnol Biofuels
; 11: 220, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30116297
9.
Comparative characterization of all cellulosomal cellulases from Clostridium thermocellum reveals high diversity in endoglucanase product formation essential for complex activity.
Biotechnol Biofuels
; 10: 240, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29075324
10.
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
EMBO Mol Med
; 3(9): 545-58, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21774078