Pesquisa | Biblioteca Virtual em Saúde

1.

Arrest of WNT/ß-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries.

Le Rolle, Morgane; Massa, Filippo; Siggers, Pam; Turchi, Laurent; Loubat, Agnès; Koo, Bon-Kyoung; Clevers, Hans; Greenfield, Andy; Schedl, Andreas; Chaboissier, Marie-Christine; Chassot, Anne-Amandine.

Proc Natl Acad Sci U S A ; 118(30)2021 07 27.

Artigo em Inglês | MEDLINE | ID: mdl-34301885

2.

Gadd45g is required for timely Sry expression independently of RSPO1 activity.

Warr, Nick; Siggers, Pam; May, Joel; Chalon, Nicolas; Pope, Madeleine; Wells, Sara; Chaboissier, Marie-Christine; Greenfield, Andy.

Reproduction ; 163(6): 333-340, 2022 04 22.

Artigo em Inglês | MEDLINE | ID: mdl-35315790

3.

25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER: Cloning, mitochondrial replacement and genome editing: 25 years of ethical debate since Dolly.

Greenfield, Andy.

Reproduction ; 162(1): F69-F78, 2021 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-33878027

4.

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.

Harris, Abigail; Siggers, Pam; Corrochano, Silvia; Warr, Nick; Sagar, Danielle; Grimes, Daniel T; Suzuki, Makoto; Burdine, Rebecca D; Cong, Feng; Koo, Bon-Kyoung; Clevers, Hans; Stévant, Isabelle; Nef, Serge; Wells, Sara; Brauner, Raja; Ben Rhouma, Bochra; Belguith, Neïla; Eozenou, Caroline; Bignon-Topalovic, Joelle; Bashamboo, Anu; McElreavey, Ken; Greenfield, Andy.

Proc Natl Acad Sci U S A ; 115(21): 5474-5479, 2018 05 22.

Artigo em Inglês | MEDLINE | ID: mdl-29735715

5.

Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.

Carré, Gwenn-Aël; Siggers, Pam; Xipolita, Marilena; Brindle, Paul; Lutz, Beat; Wells, Sara; Greenfield, Andy.

Hum Mol Genet ; 27(1): 190-198, 2018 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-29145650

6.

Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome.

McElreavey, Ken; Jorgensen, Anne; Eozenou, Caroline; Merel, Tiphanie; Bignon-Topalovic, Joelle; Tan, Daisylyn Senna; Houzelstein, Denis; Buonocore, Federica; Warr, Nick; Kay, Raissa G G; Peycelon, Matthieu; Siffroi, Jean-Pierre; Mazen, Inas; Achermann, John C; Shcherbak, Yuliya; Leger, Juliane; Sallai, Agnes; Carel, Jean-Claude; Martinerie, Laetitia; Le Ru, Romain; Conway, Gerard S; Mignot, Brigitte; Van Maldergem, Lionel; Bertalan, Rita; Globa, Evgenia; Brauner, Raja; Jauch, Ralf; Nef, Serge; Greenfield, Andy; Bashamboo, Anu.

Genet Med ; 22(1): 150-159, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31337883

7.

Fearful old world? A commentary on the Second International Summit on human genome editing.

Greenfield, Andy.

Mamm Genome ; 30(1-2): 1-4, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30600355

8.

Carry on editing.

Greenfield, Andy.

Br Med Bull ; 127(1): 23-31, 2018 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-30202929

9.

Editing mammalian genomes: ethical considerations.

Greenfield, Andy.

Mamm Genome ; 28(7-8): 388-393, 2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28653171

10.

Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.

Warr, Nick; Siggers, Pam; Carré, Gwenn-Aël; Bogani, Debora; Brixey, Rachel; Akiyoshi, Mika; Tachibana, Makoto; Teboul, Lydia; Wells, Sara; Sanderson, Jeremy; Greenfield, Andy.

Hum Mol Genet ; 23(11): 3035-44, 2014 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-24452333

11.

Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.

Warr, Nick; Siggers, Pam; Carré, Gwenn-Aël; Wells, Sara; Greenfield, Andy.

Biol Reprod ; 94(5): 103, 2016 05.

Artigo em Inglês | MEDLINE | ID: mdl-27009039

12.

Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.

Yates, Laura L; Schnatwinkel, Carsten; Hazelwood, Lee; Chessum, Lauren; Paudyal, Anju; Hilton, Helen; Romero, M Rosario; Wilde, Jonathan; Bogani, Debora; Sanderson, Jeremy; Formstone, Caroline; Murdoch, Jennifer N; Niswander, Lee A; Greenfield, Andy; Dean, Charlotte H.

Dev Biol ; 373(2): 267-80, 2013 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-23195221

13.

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

Field, Sarah; Riley, Kerry-Lyn; Grimes, Daniel T; Hilton, Helen; Simon, Michelle; Powles-Glover, Nicola; Siggers, Pam; Bogani, Debora; Greenfield, Andy; Norris, Dominic P.

Development ; 138(6): 1131-42, 2011 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-21307093

14.

SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis.

Tobias, Edward S; Lucas-Herald, Angela K; Sagar, Danielle; Montezano, Augusto C; Rios, Francisco J; De Lucca Camargo, Livia; Hamilton, Graham; Gazdagh, Gabriella; Diver, Louise A; Williams, Nicola; Herzyk, Pawel; Touyz, Rhian M; Greenfield, Andy; McGowan, Ruth; Ahmed, S Faisal.

Endocrine ; 84(2): 345-349, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38400880

15.

Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.

Pearlman, Alexander; Loke, Johnny; Le Caignec, Cedric; White, Stefan; Chin, Lisa; Friedman, Andrew; Warr, Nicholas; Willan, John; Brauer, David; Farmer, Charles; Brooks, Eric; Oddoux, Carole; Riley, Bridget; Shajahan, Shahin; Camerino, Giovanna; Homfray, Tessa; Crosby, Andrew H; Couper, Jenny; David, Albert; Greenfield, Andy; Sinclair, Andrew; Ostrer, Harry.

Am J Hum Genet ; 87(6): 898-904, 2010 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-21129722

16.

Carry on editing.

Greenfield, Andy.

Br Med Bull ; 127(1): 145, 2018 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-30032261

17.

Rationality: Science is not bad faith.

Greenfield, Andy.

Nature ; 489(7417): 502, 2012 Sep 27.

Artigo em Inglês | MEDLINE | ID: mdl-23018955

18.

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis.

Yates, Laura L; Schnatwinkel, Carsten; Murdoch, Jennifer N; Bogani, Debora; Formstone, Caroline J; Townsend, Stuart; Greenfield, Andy; Niswander, Lee A; Dean, Charlotte H.

Hum Mol Genet ; 19(11): 2251-67, 2010 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-20223754

19.

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.

Bogani, Debora; Siggers, Pam; Brixey, Rachel; Warr, Nick; Beddow, Sarah; Edwards, Jessica; Williams, Debbie; Wilhelm, Dagmar; Koopman, Peter; Flavell, Richard A; Chi, Hongbo; Ostrer, Harry; Wells, Sara; Cheeseman, Michael; Greenfield, Andy.

PLoS Biol ; 7(9): e1000196, 2009 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-19753101

20.

Homozygosity for a novel INHA mutation in two male siblings with hypospadias, primary hypogonadism, and high-normal testicular volume.

Arslan Ates, Esra; Eltan, Mehmet; Sahin, Bahadir; Gurpinar Tosun, Busra; Seven Menevse, Tuba; Geckinli, Bilgen Bilge; Greenfield, Andy; Turan, Serap; Bereket, Abdullah; Guran, Tulay.

Eur J Endocrinol ; 186(5): K25-K31, 2022 Mar 23.

Artigo em Inglês | MEDLINE | ID: mdl-35235537

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Arrest of WNT/ß-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries.

Gadd45g is required for timely Sry expression independently of RSPO1 activity.

25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER: Cloning, mitochondrial replacement and genome editing: 25 years of ethical debate since Dolly.

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.

Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.

Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome.

Fearful old world? A commentary on the Second International Summit on human genome editing.

Carry on editing.

Editing mammalian genomes: ethical considerations.

Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.

Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.

Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis.

Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.

Carry on editing.

Rationality: Science is not bad faith.

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis.

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.

Homozygosity for a novel INHA mutation in two male siblings with hypospadias, primary hypogonadism, and high-normal testicular volume.