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1.
Med Care ; 58(12): 1051-1058, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32925459

RESUMO

BACKGROUND: We previously developed 2 complementary surveys to measure coordination of care as experienced by the specialist and the primary care provider (PCP). These Coordination of Specialty Care (CSC) surveys were developed in the Veterans Health Administration (VA), under an integrated organizational umbrella that includes a shared electronic health record (EHR). OBJECTIVE: To develop an augmented version of the CSC-Specialist in the private sector and use that version (CSC-Specialist 2.0) to examine the effect of a shared EHR on coordination. RESEARCH DESIGN: We administered the survey online to a national sample of clinicians from 10 internal medicine subspecialties. We used multitrait analysis and confirmatory factor analysis to evaluate the psychometric properties of the original VA-based survey and develop an augmented private sector survey (CSC-Specialist 2.0). We tested construct validity by regressing a single-item measure of overall coordination onto the 4 scales. We used analysis of variance to examine the relationship of a shared EHR to coordination. RESULTS: Psychometric assessment supported the 13-item, 4-scale structure of the original VA measure and the augmented 18-item, 4-scale structure of the CSC-Specialist 2.0. The CSC-Specialist 2.0 scales together explained 45% of the variance in overall coordination. A shared EHR was associated with significantly better scores for the Roles and Responsibilities and Data Transfer scales, and for overall coordination. CONCLUSIONS: The CSC-Specialist 2.0 is a unique survey that demonstrates adequate psychometric performance and is sensitive to use of a shared EHR. It can be used alone or with the CSC-PCP to identify coordination problems, guide interventions, and measure improvements.


Assuntos
Continuidade da Assistência ao Paciente/organização & administração , Registros Eletrônicos de Saúde/organização & administração , Troca de Informação em Saúde , Medicina Interna/organização & administração , Inquéritos e Questionários/normas , Adulto , Atitude do Pessoal de Saúde , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Atenção Primária à Saúde/organização & administração , Setor Privado/organização & administração , Psicometria , Reprodutibilidade dos Testes , Especialização
3.
J Clin Endocrinol Metab ; 106(1): e377-e381, 2021 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-33205818

RESUMO

The coronavirus disease pandemic has created opportunities for innovation in diabetes care that were not possible before. From the lens of this "new normal" state, we have an opportunity to rapidly implement, test, and iterate models of diabetes care to achieve the quadruple aim of improving medical outcomes, patient experience, provider satisfaction, and reducing costs. In this perspective, we discuss several innovative diabetes models of care which promote collaborative care models and improve access to high-quality specialty diabetes care. We discuss ongoing threats to diabetes care innovation, and offer practical solutions to foster evolution and sustain current strides made during the pandemic.


Assuntos
COVID-19/epidemiologia , Diabetes Mellitus/terapia , SARS-CoV-2 , Humanos , Equipe de Assistência ao Paciente , Farmacêuticos , Encaminhamento e Consulta , Telemedicina
4.
J Clin Endocrinol Metab ; 89(5): 2477-83, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15126580

RESUMO

We present an unusual variant of T(4)-binding globulin (TBG) found in a family from Allentown, Pennsylvania (TBG-AT). The heterozygous proposita presented serum total T(4) and TBG levels ranging from low to normal. TBG gene sequencing revealed a C-to-T substitution in codon -2 (CAC to TAC) leading to the substitution of the normal histidine by a tyrosine within the signal peptide. No mutation within the mature peptide was found. Allele-specific PCR confirmed the H(-2)Y mutation in the propositas mother and son. T(4)-binding analysis of TBG in serum from the proposita and son showed normal affinity but reduced capacity when compared with the unaffected father. Heat stability and isoelectric focusing of TBG-AT were normal. In vitro expression of a recombinant TBG-AT in Xenopus oocytes revealed a diminished secretory efficiency and confirmed the normal binding affinity and heat stability of the small amount of secreted TBG-AT. This study has defined impaired cotranslational processing as a hitherto unrecognized cause of hereditary TBG deficiency.


Assuntos
Mutação , Sinais Direcionadores de Proteínas/genética , Proteínas de Ligação a Tiroxina/deficiência , Proteínas de Ligação a Tiroxina/genética , Adolescente , Substituição de Aminoácidos , Animais , Feminino , Histidina/genética , Humanos , Erros Inatos do Metabolismo/genética , Oócitos/metabolismo , Linhagem , RNA Mensageiro/metabolismo , Proteínas Recombinantes/metabolismo , Testes de Função Tireóidea , Glândula Tireoide/fisiologia , Tirosina/genética , Xenopus/metabolismo
5.
Thyroid ; 21(2): 151-60, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21275765

RESUMO

BACKGROUND: There is little information about the individual safety instructions provided by healthcare professionals to patients receiving radioactive iodine (I-131) therapy for the treatment of benign and malignant thyroid disorders or about whether these instructions are consistent across medical specialties. Currently, no national guidelines exist to standardize safety instructions related to I-131 administration. Here, we examine the spectrum of I-131 safety practices in contemporary use. METHODS: Members of major societies of physicians and allied specialists who treat patients with thyroid disorders were invited to complete a 27-question online survey about safety practices related to I-131 administration. Data from questionnaires were analyzed by type of safety recommendation and grouped according to provider specialty and geographic location. RESULTS: A total of 311 endocrinologists, surgeons, nuclear medicine radiologists, and allied health professionals completed questionnaires. They indicated that patients often receive instruction from more than one treating specialist. The decision to hospitalize a patient for treatment and the length of stay were determined by the patient's social situation and the dose of I-131 administered. Starting at I-131 doses between 259 and 1073 MBq (7 and 29 mCi), over 60% of respondents advised avoiding contact with children, sexual activity, and breastfeeding, with the latter recommendation continuing beyond 48 hours after treatment. Personal hygiene, laundry, and meal preparation precautions varied across respondents. Over 90% of respondents used serum or urine testing to screen for pregnancy status. Precautions to delay parenthood were given more often to female than male patients (90% vs. 60%), with a minimum recommended delay of 6 months. About 20% of respondents considered insurance coverage as a factor in selecting outpatient versus inpatient I-131 therapy, and this consideration varied geographically. CONCLUSION: A wide variety of safety recommendations are given to patients who receive I-131. To our knowledge, this survey represents the first organized inquiry into safety practices related to I-131 administration. The diversity of responses suggests an opportunity for multispecialty collaboration in defining more uniform recommendations for patient safety instructions during and after I-131 treatment.


Assuntos
Pessoal Técnico de Saúde , Radioisótopos do Iodo/administração & dosagem , Radioisótopos do Iodo/uso terapêutico , Padrões de Prática Médica , Gestão da Segurança/métodos , Doenças da Glândula Tireoide/radioterapia , Canadá , Coleta de Dados , Relação Dose-Resposta à Radiação , Bócio/radioterapia , Humanos , Hipertireoidismo/radioterapia , México , Neoplasias da Glândula Tireoide/radioterapia , Estados Unidos
6.
Thyroid ; 21(4): 335-46, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21417738

RESUMO

BACKGROUND: Radiation safety is an essential component in the treatment of patients with thyroid diseases by ¹³¹I. The American Thyroid Association created a task force to develop recommendations that would inform medical professionals about attainment of radiation safety for patients, family members, and the public. The task force was constituted so as to obtain advice, experience, and methods from relevant medical specialties and disciplines. METHODS: Reviews of Nuclear Regulatory Commission regulations and International Commission on Radiological Protection [corrected] recommendations formed the basic structure of the recommendations. Members of the task force contributed both ideas and methods that are used at their respective institutions to aid groups responsible for treatments and that instruct patients and caregivers in the attainment of radiation safety. There are insufficient data on long-term outcomes to create evidence-based guidelines. RESULTS: The information was used to compile delineations of radiation safety. Factors and situations that govern implementation of safety practices are cited and discussed. Examples of the development of tables to ascertain the number of hours or days (24-hour cycles) of radiation precaution appropriate for individual patients treated with ¹³¹I for hyperthyroidism and thyroid cancer have been provided. Reminders in the form of a checklist are presented to assist in assessing patients while taking into account individual circumstances that would bear on radiation safety. Information is presented to supplement the treating physician's advice to patients and caregivers on precautions to be adopted within and outside the home. CONCLUSION: Recommendations, complying with Nuclear Regulatory Commission regulations and consistent with guidelines promulgated by the National Council on Radiation Protection and Measurement (NCRP-155), can help physicians and patients maintain radiation safety after treatment with ¹³¹I of patients with thyroid diseases. Both treating physicians and patients must be informed if radiation safety, an integral part of therapy with ¹³¹I, is to be attained. Based on current regulations and understanding of radiation exposures, recommendations have been made to guide physicians and patients in safe practices after treatment with radioactive iodine.


Assuntos
Radioisótopos do Iodo/uso terapêutico , Proteção Radiológica/métodos , Doenças da Glândula Tireoide/radioterapia , Aleitamento Materno , Família , Feminino , Órgãos Governamentais , Humanos , Hipertireoidismo/radioterapia , Gravidez , Segurança , Sociedades Médicas , Neoplasias da Glândula Tireoide/radioterapia , Estados Unidos
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