Detalhe da pesquisa
1.
Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.
Br J Cancer
; 115(6): 682-90, 2016 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27529512
2.
A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.
Malar J
; 15(1): 535, 2016 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27821169
3.
Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases.
Org Biomol Chem
; 13(18): 5279-84, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25858034
4.
Trifluoroacetic acid in 2,2,2-trifluoroethanol facilitates S(N)Ar reactions of heterocycles with arylamines.
Chemistry
; 20(8): 2311-7, 2014 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24458729
5.
Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.
Org Biomol Chem
; 12(1): 141-8, 2014 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24213855
6.
Trifluoroethanol solvent facilitates selective N-7 methylation of purines.
Org Biomol Chem
; 11(11): 1874-8, 2013 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23381666
7.
Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response.
Int J Cancer
; 131(4): E337-47, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21913183
8.
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.
Bioorg Med Chem Lett
; 22(17): 5352-9, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22835870
9.
Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups.
Org Biomol Chem
; 10(37): 7610-7, 2012 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22893112
10.
Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.
Org Biomol Chem
; 10(33): 6747-57, 2012 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22814419
11.
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
J Med Chem
; 65(9): 6513-6540, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35468293
12.
DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.
Bioorg Med Chem Lett
; 21(3): 966-70, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21216595
13.
MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.
Bioorg Med Chem Lett
; 21(19): 5916-9, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21875801
14.
Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.
Org Biomol Chem
; 9(17): 6066-74, 2011 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21748189
15.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(7): 4071-4088, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33761253
16.
Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.
Bioorg Med Chem Lett
; 20(12): 3649-53, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20472428
17.
Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated SN2 reactivity of 2,2,2-trifluoroethoxysulfonates.
Org Biomol Chem
; 8(10): 2457-64, 2010 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20448906
18.
Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK).
Org Biomol Chem
; 8(8): 1922-8, 2010 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20449499
19.
Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.
Org Biomol Chem
; 8(10): 2397-407, 2010 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20448898
20.
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
RSC Med Chem
; 11(6): 707-731, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479670