Detalhe da pesquisa
1.
De novo designed protein inhibitors of amyloid aggregation and seeding.
Proc Natl Acad Sci U S A
; 119(34): e2206240119, 2022 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35969734
2.
Common fibrillar spines of amyloid-ß and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J Biol Chem
; 293(8): 2888-2902, 2018 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29282295
3.
Roles of the A and C sites in the manganese-specific activation of MntR.
Biochemistry
; 52(4): 701-13, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23298157
4.
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.
Nat Commun
; 14(1): 2379, 2023 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37185252
5.
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.
Proc Natl Acad Sci U S A
; 106(20): 8192-7, 2009 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19416821
6.
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proc Natl Acad Sci U S A
; 105(19): 6876-81, 2008 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18451029
7.
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
bioRxiv
; 2021 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33688654
8.
Structure-based inhibitors of amyloid beta core suggest a common interface with tau.
Elife
; 82019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31612856
9.
Atomic structures of fibrillar segments of hIAPP suggest tightly mated ß-sheets are important for cytotoxicity.
Elife
; 62017 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28045370
10.
The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
Structure
; 24(11): 1936-1946, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27692964
11.
Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.
J Med Chem
; 56(13): 5446-55, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23710599
12.
Fabs enable single particle cryoEM studies of small proteins.
Structure
; 20(4): 582-92, 2012 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22483106
13.
Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
J Mol Biol
; 388(4): 785-800, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19298824
14.
Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.
Biochemistry
; 45(11): 3493-505, 2006 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16533030