Detalhe da pesquisa
1.
Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase.
Haematologica
; 109(4): 1082-1094, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37941406
2.
Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production.
Blood
; 138(3): 234-245, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292323
3.
Mitochondrial carrier homolog 2 is necessary for AML survival.
Blood
; 136(1): 81-92, 2020 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32299104
4.
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
Proteomics
; 19(24): e1900139, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31617661
5.
Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.
Blood
; 129(19): 2657-2666, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283480
6.
The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.
Haematologica
; 104(5): 963-972, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30573504
7.
AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.
Blood
; 125(13): 2120-30, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631767
8.
Novel L-nucleoside analogue, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia.
Haematologica
; 106(2): 574-579, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31857370
9.
Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells.
Apoptosis
; 20(8): 1099-108, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25998464
10.
Mitochondrial DNA damage by bleomycin induces AML cell death.
Apoptosis
; 20(6): 811-20, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25820141
11.
Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.
Apoptosis
; 20(7): 948-59, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25832785
12.
Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies.
Am J Hematol
; 89(4): 363-8, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24273151
13.
The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.
Blood
; 115(23): 4824-33, 2010 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20348394
14.
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.
Blood
; 116(18): 3593-603, 2010 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20644115
15.
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Blood
; 115(11): 2251-9, 2010 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20075161
16.
IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells.
Leukemia
; 36(5): 1283-1295, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35152270
17.
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.
Commun Biol
; 5(1): 132, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35169231
18.
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Nat Cell Biol
; 24(6): 872-884, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35668135
19.
The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence.
Mol Pharmacol
; 79(4): 672-80, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21220410
20.
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
; 114(14): 3064-73, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19589922