Detalhe da pesquisa
1.
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats.
Toxicol Pathol
; : 1926233241248656, 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742644
2.
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.
Toxicol Pathol
; 51(1-2): 15-26, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37078689
3.
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling.
Toxicol Pathol
; 50(1): 35-46, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34657537
4.
The Utility of Novel Urinary Biomarkers in Mice for Drug Development Studies.
Int J Toxicol
; 40(1): 15-25, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33161787
5.
Performance Assessment of New Urinary Translational Safety Biomarkers of Drug-induced Renal Tubular Injury in Tenofovir-treated Cynomolgus Monkeys and Beagle Dogs.
Toxicol Pathol
; 46(5): 553-563, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29807506
6.
Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis.
Arthritis Rheum
; 63(12): 3988-97, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21953143
7.
Early events in vascular injury in the rat induced by the phosphodiesterase IV inhibitor SCH 351591.
Toxicol Pathol
; 38(5): 738-44, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20585143
8.
Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development.
Birth Defects Res B Dev Reprod Toxicol
; 89(6): 474-84, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21058326
9.
Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia.
Toxicology
; 439: 152462, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32348786
10.
Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.
Toxicol Sci
; 172(1): 155-166, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31406999
11.
Validation of putative genomic biomarkers of nephrotoxicity in rats.
Toxicology
; 246(2-3): 91-100, 2008 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18289764
12.
Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385.
Toxicol Pathol
; 36(6): 840-9, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18776166
13.
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Drug Chem Toxicol
; 31(4): 501-13, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18850359
14.
In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies.
Toxicol Sci
; 99(1): 162-73, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17567588
15.
Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury.
Toxicol Sci
; 151(2): 214-23, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27026710
16.
Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies.
Toxicol Sci
; 138(1): 3-20, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24361871
17.
Toxicoepigenetic alteration of the kidney injury molecule 1 gene in gentamicin-exposed rat kidney.
Toxicol Sci
; 117(2): 375-80, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660082
18.
Towards consensus practices to qualify safety biomarkers for use in early drug development.
Nat Biotechnol
; 28(5): 446-54, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20458314
19.
Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium.
Nat Biotechnol
; 28(5): 455-62, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20458315
20.
Co-induction of CYP3A12 and 3A26 in dog liver slices by xenobiotics: species difference between human and dog CYP3A induction.
Drug Metab Lett
; 3(1): 61-6, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356119