Detalhe da pesquisa
1.
Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response.
Proc Natl Acad Sci U S A
; 119(36): e2206327119, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037380
2.
Unveiling Novel ERCC1-XPF Complex Inhibitors: Bridging the Gap from In Silico Exploration to Experimental Design.
Int J Mol Sci
; 25(2)2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279246
3.
Using Machine Learning and Molecular Docking to Leverage Urease Inhibition Data for Virtual Screening.
Int J Mol Sci
; 24(9)2023 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37175889
4.
Exploring the Chemical Space of Urease Inhibitors to Extract Meaningful Trends and Drivers of Activity.
J Chem Inf Model
; 62(15): 3535-3550, 2022 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35666858
5.
Bromoditerpenes from the Red Seaweed Sphaerococcus coronopifolius as Potential Cytotoxic Agents and Proteasome Inhibitors and Related Mechanisms of Action.
Mar Drugs
; 20(10)2022 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36286475
6.
Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors.
Molecules
; 27(15)2022 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35897894
7.
Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance.
Molecules
; 27(7)2022 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35408601
8.
Computational Modulation of the V3 Region of Glycoprotein gp125 of HIV-2.
Int J Mol Sci
; 22(4)2021 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33669351
9.
Synthesis of Computationally Designed 2,5(6)-Benzimidazole Derivatives via Pd-Catalyzed Reactions for Potential E. coli DNA Gyrase B Inhibition.
Molecules
; 26(5)2021 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33801316
10.
Exploring EZH2-Proteasome Dual-Targeting Drug Discovery through a Computational Strategy to Fight Multiple Myeloma.
Molecules
; 26(18)2021 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34577052
11.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.
Molecules
; 25(13)2020 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32605268
12.
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor.
Bioorg Med Chem
; 27(2): 354-363, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30578075
13.
Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design.
Int J Mol Sci
; 20(21)2019 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31731563
14.
Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models.
Int J Mol Sci
; 20(20)2019 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31618886
15.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.
Molecules
; 25(1)2019 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31905602
16.
Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches.
Biochemistry
; 55(51): 7086-7098, 2016 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27976856
17.
Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview.
Molecules
; 21(7)2016 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27438821
18.
3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: inhibition of rat intestinal α-glucosidase.
Bioorg Chem
; 54: 81-8, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24859324
19.
Inferring molecular inhibition potency with AlphaFold predicted structures.
Sci Rep
; 14(1): 8252, 2024 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38589418
20.
Development of New Drugs to Treat Tuberculosis Based on the Dinitrobenzamide Scaffold.
Pharmaceuticals (Basel)
; 17(5)2024 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38794129