Detalhe da pesquisa
1.
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.
Biochem Pharmacol
; 73(11): 1829-41, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17433263
2.
The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.
Cancer Res
; 65(10): 4425-30, 2005 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15899835
3.
The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens.
Mol Cancer Ther
; 1(13): 1211-20, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12479702
4.
An Integrated Assessment Scheme for assessing the adequacy of (eco)toxicological data under REACH.
Toxicol Lett
; 198(2): 255-62, 2010 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20633615
5.
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.
Cancer Res
; 70(4): 1700-10, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20145144
6.
Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen.
Drug Metab Dispos
; 32(3): 321-7, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-14977866
7.
Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse.
Drug Metab Dispos
; 31(6): 718-26, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12756203
8.
Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice.
J Pharmacol Exp Ther
; 301(1): 77-86, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11907160