Detalhe da pesquisa
1.
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.
Bioorg Med Chem Lett
; 30(16): 127072, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32340773
2.
Discovery of hydroxy pyrimidine Factor IXa inhibitors.
Bioorg Med Chem Lett
; 30(15): 127279, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32527459
3.
Unraveling the structural basis of grazoprevir potency against clinically relevant substitutions in hepatitis C virus NS3/4A protease from genotype 1a.
J Biol Chem
; 292(15): 6202-6212, 2017 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28228479
4.
Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.
Bioorg Med Chem Lett
; 27(14): 3037-3042, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28558971
5.
PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.
Blood
; 124(11): 1777-89, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006129
6.
The importance of protonation and tautomerization in relative binding affinity prediction: a comparison of AMBER TI and Schrödinger FEP.
J Comput Aided Mol Des
; 30(7): 533-9, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27480697
7.
Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
J Biol Chem
; 288(42): 30125-30138, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24003220
8.
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Bioorg Med Chem Lett
; 23(11): 3262-6, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602398
9.
Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.
Structure
; 30(7): 947-961.e6, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35460613
10.
The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria.
ACS Med Chem Lett
; 13(11): 1745-1754, 2022 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385924
11.
Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.
J Med Chem
; 65(7): 5575-5592, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35349275
12.
2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.
Bioorg Med Chem Lett
; 21(10): 3172-6, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21458257
13.
Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.
J Immunol
; 183(6): 3873-84, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19717519
14.
Identification of HCV protease inhibitor resistance mutations by selection pressure-based method.
Nucleic Acids Res
; 37(10): e74, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19395595
15.
SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Mol Cancer Ther
; 20(2): 250-262, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310762
16.
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.
Bioorg Med Chem Lett
; 20(5): 1689-92, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149655
17.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg Med Chem Lett
; 20(8): 2617-21, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303756
18.
Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
Bioorg Med Chem Lett
; 20(24): 7283-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106451
19.
Structure and activity relationships of tartrate-based TACE inhibitors.
Bioorg Med Chem Lett
; 20(16): 4812-5, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20638281
20.
Biaryl substituted hydantoin compounds as TACE inhibitors.
Bioorg Med Chem Lett
; 20(17): 5286-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20663669