Detalhe da pesquisa
1.
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
J Med Chem
; 67(7): 5758-5782, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511649
2.
Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates.
J Neurosci
; 32(2): 411-6, 2012 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22238077
3.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J Med Chem
; 65(24): 16290-16312, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36469401
4.
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Clin Pharmacol Ther
; 107(2): 406-414, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31437302
5.
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron
; 105(5): 837-854.e9, 2020 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902528
6.
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models.
Cell Rep
; 22(3): 832-847, 2018 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29346778
7.
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1.
Neuron
; 111(8): 1348, 2023 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37080170
8.
A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains.
J Alzheimers Dis
; 56(3): 1037-1054, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28106546
9.
Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor.
PLoS One
; 9(1): e84823, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24400119
10.
Missense variant in TREML2 protects against Alzheimer's disease.
Neurobiol Aging
; 35(6): 1510.e19-26, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24439484
11.
VEGF mediates commissural axon chemoattraction through its receptor Flk1.
Neuron
; 70(5): 966-78, 2011 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21658588
12.
Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.
Science
; 314(5796): 144-8, 2006 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17023663