Detalhe da pesquisa
1.
Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes.
J Am Chem Soc
; 143(10): 4055-4063, 2021 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666086
2.
Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins.
J Am Chem Soc
; 143(1): 97-102, 2021 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33369395
3.
Development of targeted protein degradation therapeutics.
Nat Chem Biol
; 15(10): 937-944, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31527835
4.
SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate.
Nat Chem Biol
; 14(10): 981-987, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30190590
5.
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Bioorg Med Chem
; 28(12): 115548, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503688
6.
Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
J Pharmacol Exp Ther
; 367(1): 147-154, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30076263
7.
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
Nat Chem Biol
; 11(7): 511-7, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26030728
8.
Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Drug Metab Dispos
; 44(6): 809-20, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27029743
9.
Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.
Bioorg Med Chem Lett
; 26(1): 160-7, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26584882
10.
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
Nature
; 465(7294): 96-100, 2010 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20410884
11.
Accessing Drug Metabolites via Transition-Metal Catalyzed C-H Oxidation: The Liver as Synthetic Inspiration.
Angew Chem Int Ed Engl
; 55(46): 14218-14238, 2016 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27723189
12.
Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett
; 24(21): 5045-9, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25266782
13.
2-Alkyloxazoles as potent and selective PI4KIIIß inhibitors demonstrating inhibition of HCV replication.
Bioorg Med Chem Lett
; 24(16): 3714-8, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25065492
14.
Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
Nat Chem Biol
; 12(4): 304, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26991088
15.
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 23(6): 1622-5, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23416006
16.
Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Biochem Pharmacol
; 209: 115418, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36693437
17.
Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2).
J Med Chem
; 66(23): 15750-15760, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38009718
18.
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.
J Med Chem
; 66(13): 9095-9119, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37399505
19.
Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
Nat Chem Biol
; 11(9): 741, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26284678
20.
The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.
J Gen Virol
; 92(Pt 11): 2502-2511, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21795470