Nurse-Initiated Protocol to Improve Timely Antibiotic Administration in Pediatric Open Fractures.

BACKGROUND: Early administration of antibiotics in the presence of open fractures is critical in reducing infections and later complications. Current guidelines recommend administering antibiotics within 60 min of patient arrival to the emergency department, yet trauma centers often struggle to meet this metric. OBJECTIVES: This study aims to evaluate the impact of a nurse-initiated evidence-based treatment protocol on the timeliness of antibiotic administration in pediatric patients with open fractures. METHODS: A retrospective pre-post study of patients who met the National Trauma Data Standard registry inclusion criteria for open fractures of long bones, amputations, or lawn mower injuries was performed at a Midwestern United States Level II pediatric trauma center. The time of patient arrival and time of antibiotic administration from preimplementation (2015-2020) to postimplementation (2021-2022) of the protocol were compared. Patients transferred in who received antibiotics at an outside facility were excluded. RESULTS: A total of N = 73 participants met the study inclusion criteria, of which n = 41 were in the preimplementation group and n = 32 were in the postimplementation group. Patients receiving antibiotics within 60 min of arrival increased from n = 24/41 (58.5%) preimplementation to n = 26/32 (84.4%) postimplementation (p< .05). CONCLUSIONS: Our study demonstrates that initiating evidence-based treatment orders from triage helped decrease the time from arrival to time of antibiotic administration in patients with open fractures. We sustained improvement for 24 months after the implementation of our intervention.

Using Fundamental Spectroscopy to Elucidate Kinetic and Energetic Mechanisms within Environmentally Relevant Inductively Coupled Plasma Systems.

Understanding energy distributions and kinetic processes in NxOy plasma systems is vital to realizing their potential in a range of applications, including pollution abatement. Energy partitioning between degrees of freedom and multiple molecules formed within NxOy plasma systems (N2, N2O, N2/O2) was investigated using both optical emission and broadband absorption spectroscopies. Specifically, we determined electron temperatures (Te) as well as rotational (TR) and vibrational (TV) temperatures for various N2 (B3Πg and C3Πu) and NO (X2Π and A2Σ+) states. TR and TV for both molecules (regardless of state) show a strong positive correlation with applied plasma power, as well as a negative correlation with system pressure. In all cases, TV values are significantly higher than TR for both species, suggesting vibrational modes are preferentially excited over rotational degrees of freedom. Time-resolved optical emission spectroscopy was utilized to determine rate constants, providing mechanistic insight and establishing the relationships between system parameters and plasma chemistry. Ultimately, the combination of these data allows us to glean information regarding both the kinetics and energetics of N2 and NO molecules formed within nitrogen- and oxygen-containing plasma systems for potential applications in gas remediation of pollutants.

Kids gone wild - Alcohol use and patient characteristics in pediatric trauma during the coronavirus disease 2019 pandemic.

Importance: Reported coronavirus disease 2019 (COVID-19) pandemic effects on pediatric trauma have been variable. Objective: We investigated the characteristics of pediatric trauma including alcohol use during the pandemic at our urban trauma center. Methods: The trauma database of our adult level 1 trauma center was queried for all pediatric (age ≤ 18 years) patients presenting between March 1, 2020, and October 30, 2020. Data from 2017 to 2019 served as a control. Variables analyzed included demographics, mechanisms, injury severity, hospitalization characteristics, and positive blood alcohol. Results: Pandemic pediatric trauma volumes increased by 67.5% (330/year vs. 197/year). Pandemic patients were younger (median age 13 vs. 14 years, P = 0.011), but similar in gender, ethnicity, severity, hospital length of stay, mortality, and rates of penetrating injury. Falls doubled (79/year vs. 34/year) and shifted away from high falls >6 meters (0% vs. 7.9%) to moderate falls 1-6 meters (58.2% vs. 51.5%) (P = 0.028). Transportation injury rates were similar however mechanisms shifted from motor vehicle crashes (-13.5%) towards recreational vehicles including motorcycles (+2.1%), all-terrain vehicles (+8.6%), and bicycles (+3.8%) (P = 0.018). Pediatric-positive blood alcohol was significantly higher (11.2% vs. 5.1%, P < 0.001), especially for ages 14-18 years (21.7% vs. 9.5%, P < 0.001). Interpretation: Pediatric trauma volumes during the COVID-19 pandemic increased. Pandemic patients had more recreational vehicle injuries and higher rates of positive blood alcohol. This suggests an increased need for alcohol assessment and targeted interventions in the pediatric population during pandemics or periods of school closures.

Life-threatening postoperative hemorrhage from hepatic artery pseudoaneurysm successfully treated by transcatheter embolization in a 5-year-old.

Upper gastrointestinal bleeding caused by a pseudoaneurysm after hepatobiliary operation is well described in adults. This can be successfully treated with transcatheter embolization under angiographic guidance. We report a case of massive upper gastrointestinal bleeding in a 5-year-old boy secondary to a pseudoaneurysm of the right hepatic artery after choledochal cyst excision. A coil embolization successfully treated this life-threatening event and spared the child, the morbidity of a challenging gastrointestinal and vascular reconstruction. Use of percutaneous interventional technique to treat this rare complication of choledochal cyst excision has not been previously described in the pediatric surgical literature. Transcatheter embolization of a pseudoaneurysm may be a safe and less morbid treatment alternative for this surgical complication even in the pediatric population.

Minimally invasive Heller's myotomy in children: safe and effective.

PURPOSE: The aim of the study was to review a single institution experience of minimally invasive Heller's myotomy in pediatric patients with achalasia. METHODS: An institutional review board-approved retrospective review from 1999 to 2005 identified patients 18 years old and younger who underwent a minimally invasive Heller's myotomy for achalasia. RESULTS: Twenty-six patients were identified with a mean age of 15 (range, 4-18 years). There were 11 female and 15 male patients. There were 3 intraoperative complications (2 esophageal mucosal injuries and 1 aspiration). There was no mortality. All 26 surgeries were completed laparoscopically. Two patients had Dor fundoplication, whereas 23 patients had Toupet fundoplication. Average length of hospital stay was 2.7 days (range, 1-4 days) excluding the 3 patients with intraoperative complications and 3.5 days for all patients (range, 1-17 days). Postoperative follow-up ranged from 0 to 75 months (mean, 20 months). Postoperatively, one patient developed reflux symptoms (incidence 4%). Seven patients (27%) had recurrence of symptoms at a mean of 13 months (range, 1-66 months) after their operation. CONCLUSIONS: Laparoscopic Heller's myotomy with fundoplication is a safe and effective treatment of symptomatic achalasia in the pediatric population. Complications were low in this group of patients and comparable to other published reports in the literature.

Minimally invasive repair for pectus excavatum in adults.

BACKGROUND: The purpose of this study is to review the minimally invasive pectus excavatum repair in adults to determine the safety and effectiveness. METHODS: An Institutional Review Board approved chart review identified patients 17 years or older who underwent minimally invasive pectus excavatum repair (MIPER) between January 1999 and January 2004. RESULTS: Nineteen patients underwent MIPER. Indications for surgery were reduced exercise tolerance (13), dyspnea on exertion (17), improve self-perception (10), and chest pain (6). There were no intraoperative complications or conversions to open repair. Twelve patients (63%) required one strut and seven patients (37%) required two struts. Postoperative complications included self-resolving asymptomatic pneumothorax in six patients and pneumonia in one. Pain at six weeks postoperatively was mild to none in most patients and all had no pain at three months postoperatively except one patient with strut displacement. Two patients required removal of one of two struts due to displacement. The mean postoperative pectus index was significantly lower than preoperative value: 2.5 versus 4.6, p = 0.002. Among six patients with strut removal at two years postoperatively, two patients had mild recurrence of their deformity. CONCLUSIONS: Minimally invasive pectus excavatum repair can be performed safely in adults. This approach is technically more challenging in adults with one-third of the patients requiring two struts for optimal repair. The risk of strut displacement is higher than in the pediatric population. The long-term effectiveness and durability of this procedure in adults is still unknown.

Outcome of adrenocortical tumors in children.

PURPOSE: This study reviews adrenocortical tumors in children to determine factors that significantly affect outcome. METHODS: An institutional review board-approved retrospective review from 1976 to 2005 identified 23 patients younger than 19 years old with histologic confirmation of adrenocortical carcinoma (ACC) and adenomas. RESULTS: The mean age of the 23 children was 9.0 +/- 1.6 years; girls predominated (female-to-male ratio = 1.9:1) as did cancers (ACC 16, adenoma 7); tumor hormone production (74%); and advanced stage for disease (66%). All malignancies were more than 2.5 cm. Adrenalectomy, including en bloc resection of adjacent structures (35%) achieved grossly negative margins in 70% of patients. Three patients received chemotherapy or chemoradiation as primary treatment without surgery. There was no perioperative mortality; morbidity was 10% (pneumothorax, acute renal failure, chylous ascites, and thrombocytosis). Surgical cure without adjuvant therapy was achieved for all adenomas and ACC stages I and II. For ACC stage III and IV, median survival was 21 months, 5-year survival was 0%. All advanced-staged ACC received adjuvant therapy. Surgically negative margins conferred a survival advantage. CONCLUSIONS: Children, especially females with ACC present with large advanced-staged tumors. Surgically negative margins with or without en bloc resection improves survival. The high percentage of children with functioning tumors suggests earlier detection is possible.

Pancreatic pseudocyst in children: the impact of management strategies on outcome.

INTRODUCTION: Persistent pancreatic pseudocysts (PPs) are rare in childhood and management tends to be individualized. The purpose of this review is to determine the impact of different management strategies and to analyze their effects on patient outcomes. METHODS: An institutional review board-approved retrospective chart review was performed on children younger than 18 years who had PP diagnosed between January 1976 and December 2003. RESULTS: There were 24 patients, 13 male and 11 female, with a mean age 10.7 years (range, 2-17 years). The mean PP size was 5.8 cm (range, 1.7-20 cm). Posttraumatic pseudocysts were identified in 11 children. The etiologies of 13 nontraumatic PP were idiopathic (6), familial pancreatitis (4), drug-induced (1), cholelithiasis (1), and bifid duct (1). All patients were symptomatic at diagnosis. Resolution of pseudocysts without operative intervention occurred in 7 (29%) of 24 patients. The mean time to operation for the remaining 17 children (71%) was 13.1 weeks (range, 6-36 weeks), with indications for intervention including persistent/recurrent abdominal pain (17), failure to thrive (9), infected PP (1), and ruptured PP (1). Surgical therapies for 13 of 17 patients consisted of cystogastrostomy (8), cystojejunostomy (2), longitudinal pancreaticojejunostomy (2), and Frey's procedure (1). Four patients underwent pancreatic sphincterotomy and stenting, 2 of whom also had image-guided pseudocyst drainage. The intervention-related mortality and morbidity rates were 0% and 11%, respectively, for children undergoing surgical therapies. The morbidities included pancreatic leak (1) and wound infection (1). Etiology of the PP had a significant influence on the need for intervention (traumatic, 45%; nontraumatic, 92%; P = .02); however, patient age, size, and location of the PP had no significant effect. All 24 patients continued to do well at mean follow-up of 73.3 months (range, 6 weeks-25 years). One patient with idiopathic pancreatitis has since developed insulin-dependent diabetes. All 4 patients with familial pancreatitis had their chronic pain improved without long-term narcotic therapy. CONCLUSION: The treatment of PPs in children is dependent on etiology, where pseudocysts from nontraumatic etiologies are more likely to require and benefit from surgical interventions, whereas pseudocysts from traumatic etiology are more amenable to conservative management. For children with persistent symptoms or interval complication, surgical therapy is safe and effective.

Increasing prevalence of gastroschisis in Utah.

BACKGROUND: Recent studies provide conflicting information about gastroschisis prevalence trends. The authors proposed that prevalence of gastroschisis in live births has increased in Utah and that characteristics of these infants would provide clinically useful information about treatment and outcomes. METHODS: Primary Children's Medical Center (PCMC) is the sole pediatric surgical referral hospital for Utah. The authors used both pediatric surgical and neonatal databases to identify gastroschisis cases at PCMC from 1971 through 2002. Only infants whose mothers had a primary residence in Utah were included. Individual charts were reviewed for infant characteristics for cases from 1998 through 2002. Utah Vital Statistics Reports were used to determine live birth rates and general infant and maternal characteristics. RESULTS: Gastroschisis prevalence increased from 0.36 to 3.92 cases per 10,000 live births over 31 years (P < .001). Young maternal age, primigravida status, and tobacco use were associated risk factors. Using the time required to achieve full enteric feedings at targeted volume and caloric density as a measurement of outcome, we found no association between delivery mode or surgical closure type (primary or secondary) and time to full feedings. Higher birth weight was associated with decreased time to full feedings (P = .03). CONCLUSIONS: Gastroschisis prevalence has increased 10-fold over the past 3 decades in Utah.