Detalhe da pesquisa
1.
Enabling, Decagram-Scale Synthesis of Macrocyclic MCL-1 Inhibitor ABBV-467.
J Org Chem
; 88(22): 15562-15568, 2023 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37909857
2.
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 27(15): 3317-3325, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28610984
3.
A robust in vivo positive-readout system for monitoring siRNA delivery to xenograft tumors.
RNA
; 17(4): 603-12, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21321186
4.
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Commun Med (Lond)
; 3(1): 154, 2023 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37880389
5.
Total synthesis of phorboxazole A via de novo oxazole formation: convergent total synthesis.
J Am Chem Soc
; 133(5): 1506-16, 2011 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190384
6.
Total synthesis of phorboxazole A via de novo oxazole formation: strategy and component assembly.
J Am Chem Soc
; 133(5): 1484-505, 2011 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190385
7.
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor.
ACS Med Chem Lett
; 11(10): 1829-1836, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062160
8.
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.
ACS Med Chem Lett
; 9(1): 28-33, 2018 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348807
9.
N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.
J Med Chem
; 50(5): 1078-82, 2007 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17298049
10.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368119
11.
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol Cancer Ther
; 16(7): 1236-1245, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28468779
12.
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
J Med Chem
; 49(13): 3770-3, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789734
13.
Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.
J Med Chem
; 55(4): 1751-7, 2012 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22263872
14.
Design and total synthesis of a fluorescent phorboxazole A analog for cellular studies.
Bioorg Med Chem Lett
; 16(4): 901-4, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16300946
15.
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Bioorg Med Chem Lett
; 16(23): 6078-81, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16973360
16.
Total synthesis of a biotinylated derivative of phorboxazole A via sonogashira coupling.
Bioorg Med Chem Lett
; 13(13): 2127-30, 2003 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12798319