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Hum Genomics
; 18(1): 7, 2024 Jan 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38291512
RESUMO
The present study investigated two single nucleotide polymorphisms (SNPs)-rs479200 and rs516651 in the host EGLN1/PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 COVID-19 patients from the Indian population (March 2020 to June 2021) was enrolled. Notably, the frequency of C allele (0.664) was twofold higher than T allele (0.336) in severe COVID-19 patients. Here, we report a novel finding that the C allele of rs479200 in the EGLN1 gene imparts a high risk of severe COVID-19 (odds ratio-6.214 (1.84-20.99) p = 0.003; 9.421 (2.019-43.957) p = 0.004), in additive inheritance model (adjusted and unadjusted, respectively).
Assuntos
COVID-19 , Humanos , Alelos , Estudos Retrospectivos , COVID-19/epidemiologia , COVID-19/genética , Polimorfismo de Nucleotídeo Único/genética , Povo Asiático , Predisposição Genética para Doença , Frequência do Gene , Prolina Dioxigenases do Fator Induzível por Hipóxia/genética
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