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1.
Environ Sci Technol ; 50(22): 12464-12472, 2016 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-27700069

RESUMO

Exposures to environmental pollutants in utero may increase the risk of adverse health effects. We measured the concentrations of 59 potentially harmful chemicals in 77 maternal and 65 paired umbilical cord blood samples collected in San Francisco during 2010-2011, including polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and perfluorinated compounds (PFCs) in serum and metals in whole blood. Consistent with previous studies, we found evidence that concentrations of mercury (Hg) and lower-brominated PBDEs were often higher in umbilical cord blood or serum than in maternal samples (median cord:maternal ratio > 1), while for most PFCs and lead (Pb), concentrations in cord blood or serum were generally equal to or lower than their maternal pair (median cord:maternal ratio ≤ 1). In contrast to the conclusions of a recent review, we found evidence that several PCBs and OCPs were also often higher in cord than maternal serum (median cord:maternal ratio > 1) when concentrations are assessed on a lipid-adjusted basis. Our findings suggest that for many chemicals, fetuses may experience higher exposures than their mothers and highlight the need to characterize potential health risks and inform policies aimed at reducing sources of exposure.


Assuntos
Poluentes Ambientais , Éteres Difenil Halogenados , Exposição Materna , Monitoramento Ambiental , Feminino , Humanos , Hidrocarbonetos Clorados , Recém-Nascido , Troca Materno-Fetal , Bifenilos Policlorados , Gravidez , São Francisco , População Urbana
2.
Artigo em Inglês | MEDLINE | ID: mdl-31906553

RESUMO

Many California nail salon workers are low-income Vietnamese women of reproductive age who use nail products daily that contain androgen-disrupting phthalates, which may increase risk of male reproductive tract abnormalities during pregnancy. Yet, few studies have characterized phthalate exposures among this workforce. To characterize individual metabolites and cumulative phthalates exposure among a potentially vulnerable occupational group of nail salon workers, we collected 17 post-shift urine samples from Vietnamese workers at six San Francisco Bay Area nail salons in 2011, which were analyzed for four primary phthalate metabolites: mono-n-butyl-, mono-isobutyl-, mono(2-Ethylhexyl)-, and monoethyl phthalates (MnBP, MiBP, MEHP, and MEP, respectively; µg/L). Phthalate metabolite concentrations and a potency-weighted sum of parent compound daily intake (Σandrogen-disruptor, µg/kg/day) were compared to 203 Asian Americans from the 2011-2012 National Health and Nutritional Examination Survey (NHANES) using Student's t-test and Wilcoxin signed rank test. Creatinine-corrected MnBP, MiBP, MEHP (µg/g), and cumulative phthalates exposure (Σandrogen-disruptor, µg/kg/day) levels were 2.9 (p < 0.0001), 1.6 (p = 0.015), 2.6 (p < 0.0001), and 2.0 (p < 0.0001) times higher, respectively, in our nail salon worker population compared to NHANES Asian Americans. Levels exceeded the NHANES 95th or 75th percentiles among some workers. This pilot study suggests that nail salon workers are disproportionately exposed to multiple phthalates, a finding that warrants further investigation to assess their potential health significance.


Assuntos
Asiático/estatística & dados numéricos , Indústria da Beleza/estatística & dados numéricos , Poluentes Ambientais/urina , Exposição Ocupacional/análise , Ácidos Ftálicos/urina , Adulto , Monitoramento Biológico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , São Francisco , Vietnã/etnologia , Adulto Jovem
3.
J Occup Environ Med ; 57(1): 88-97, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25563545

RESUMO

OBJECTIVE: To assess California firefighters' blood concentrations of selected chemicals and compare with a representative US population. METHODS: We report laboratory methods and analytic results for cadmium, lead, mercury, and manganese in whole blood and 12 serum perfluorinated chemicals in a sample of 101 Southern California firefighters. RESULTS: Firefighters' blood metal concentrations were all similar to or lower than the National Health and Nutrition Examination Survey (NHANES) values, except for six participants whose mercury concentrations (range: 9.79 to 13.42 µg/L) were close to or higher than the NHANES reporting threshold of 10 µg/L. Perfluorodecanoic acid concentrations were elevated compared with NHANES and other firefighter studies. CONCLUSIONS: Perfluorodecanoic acid concentrations were three times higher in this firefighter group than in NHANES adult males. Firefighters may have unidentified sources of occupational exposure to perfluorinated chemicals.


Assuntos
Monitoramento Ambiental/métodos , Bombeiros , Incêndios , Exposição Ocupacional/análise , Adulto , Fatores Etários , Ácidos Alcanossulfônicos/sangue , Cádmio/sangue , California , Ácidos Decanoicos/sangue , Ácidos Graxos , Feminino , Fluorocarbonos/sangue , Ácidos Heptanoicos/sangue , Humanos , Hidrocarbonetos Fluorados/sangue , Chumbo/sangue , Masculino , Manganês/sangue , Mercúrio/sangue , Pessoa de Meia-Idade , Inquéritos Nutricionais , Exposição Ocupacional/normas , Sulfonamidas/sangue , Adulto Jovem
4.
Mar Pollut Bull ; 73(1): 231-42, 2013 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-23746941

RESUMO

Despite scientific and public concern, research on food web contamination from chemicals in plastic is limited, and distinguishing plastic sources from prey remains a challenge. We analyzed juvenile yellowtail (Seriola lalandi) from the North Pacific Central Gyre for plastic ingestion and tissue concentrations of persistent organic pollutants and nonionic surfactants to investigate potential contamination from plastic exposure. Ingestion of synthetic debris occurred in ~10% of the sample population. PCBs and DDTs were 352±240 (mean±SD) and 1425±1118 ng/g lw, respectively. PBDEs were 9.08±10.6 ng/g lw, with BDEs-47, 99, and 209 representing 90% of PBDEs. Nonylphenol (NP) was detected in one-third of the yellowtail with a mean of 52.8±88.5 ng/g ww overall and 167±72.3 ng/g ww excluding non-detects. Because environmental NP is strongly associated with wastewater treatment effluents, long-range transport is unlikely, and NP was previously measured in gyre plastic, we concluded that plastic-mediated exposure best explained our findings of NP in yellowtail.


Assuntos
Monitoramento Ambiental , Peixes/metabolismo , Fenóis/metabolismo , Poluentes Químicos da Água/metabolismo , Animais , Cadeia Alimentar , Oceano Pacífico , Fenóis/análise , Plásticos/análise , Plásticos/metabolismo , Bifenilos Policlorados/análise , Bifenilos Policlorados/metabolismo , Poluentes Químicos da Água/análise , Poluição Química da Água/estatística & dados numéricos
5.
Environ Toxicol Chem ; 30(11): 2562-9, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21898564

RESUMO

Here we report the first measurements of polybrominated diphenyl ethers (PBDE 47, 99, and 153) alongside 11 organochlorine pesticides (OCPs) and 28 polychlorinated biphenyls (PCBs) in the plasma of albatross from breeding colonies distributed across a large spatial east-west gradient in the North Pacific Ocean. North Pacific albatross are wide-ranging, top-level consumers that forage in pelagic regions of the North Pacific Ocean, making them an ideal sentinel species for detection and distribution of marine contaminants. Our work on contaminant burdens in albatross tissue provides information on transport of persistent organic pollutants (POPs) to the remote North Pacific and serves as a proxy for regional environmental quality. We sampled black-footed (Phoebastria nigripes; n = 20) and Laysan albatross (P. immutabilis; n = 19) nesting on Tern Island, Hawaii, USA, and Laysan albatross (n = 16) nesting on Guadalupe Island, Mexico. Our results indicate that North Pacific albatross are highly exposed to both PCBs and OCPs, with levels ranging from 8.8 to 86.9 ng/ml wet weight and 7.4 to 162.3 ng/ml wet weight, respectively. A strong significant gradient exists between Laysan albatross breeding in the Eastern Pacific, having approximately 1.5-fold and 2.5-fold higher levels for PCBs and OCPs, respectively, compared to those from the Central Pacific. Interspecies levels of contaminants within the same breeding site also showed high variation, with Tern black-footed albatross having approximately threefold higher levels of both PCBs and OCPs than Tern Laysan albatross. Surprisingly, while PBDEs are known to travel long distances and bioaccumulate in wildlife of high trophic status, we detected these three PBDE congeners only at trace levels ranging from not detectable (ND) to 0.74 ng/ml wet weight in these albatross.


Assuntos
Aves/sangue , Éteres Difenil Halogenados/sangue , Hidrocarbonetos Clorados/sangue , Resíduos de Praguicidas/sangue , Bifenilos Policlorados/sangue , Animais , Monitoramento Ambiental , Poluentes Ambientais/sangue , Havaí , México , Oceano Pacífico
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