Detalhe da pesquisa
1.
Improvements in immune/melanocyte biomarkers with JAK3/TEC family kinase inhibitor ritlecitinib in vitiligo.
J Allergy Clin Immunol
; 153(1): 161-172.e8, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37777018
2.
Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study.
Clin Gastroenterol Hepatol
; 21(10): 2616-2628.e7, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36623678
3.
Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study.
Clin Gastroenterol Hepatol
; 19(11): 2324-2332.e6, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34126262
4.
First-in-human, randomized dose-escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF-06480605 in healthy subjects.
Br J Clin Pharmacol
; 86(4): 812-824, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31758576
5.
Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn's disease: report of the OPERA study.
Gut
; 67(10): 1824-1835, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28982740
6.
Anti-MAdCAM antibody (PF-00547659) for ulcerative colitis (TURANDOT): a phase 2, randomised, double-blind, placebo-controlled trial.
Lancet
; 390(10090): 135-144, 2017 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28527704
7.
A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis.
Arthritis Res Ther
; 26(1): 117, 2024 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38845046
8.
Cytosolic phospholipase A2α blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.
J Immunol
; 187(4): 1986-97, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21746963
9.
Baseline serum and stool microbiome biomarkers predict clinical efficacy and tissue molecular response after ritlecitinib induction therapy in ulcerative colitis.
J Crohns Colitis
; 2023 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38141256
10.
A shared tissue transcriptome signature and pathways in psoriasis and ulcerative colitis.
Sci Rep
; 12(1): 19740, 2022 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36396672
11.
Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis.
Inflamm Bowel Dis
; 28(3): 434-446, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34427649
12.
Anti-MAdCAM-1 antibody (PF-00547659) for active refractory Crohn's disease in Japanese and Korean patients: the OPERA study.
Intest Res
; 18(1): 45-55, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32013314
13.
Molecular Profiling of Ulcerative Colitis Subjects from the TURANDOT Trial Reveals Novel Pharmacodynamic/Efficacy Biomarkers.
J Crohns Colitis
; 13(6): 702-713, 2019 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30901380
14.
Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.
J Neuroimmunol
; 204(1-2): 29-37, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18829119
15.
Targeting Endothelial Ligands: ICAM-1/alicaforsen, MAdCAM-1.
J Crohns Colitis
; 12(suppl_2): S669-S677, 2018 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29757363
16.
Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn's Disease.
J Crohns Colitis
; 12(1): 77-86, 2018 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28961803
17.
Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating ß7+ T Cells in Crohn's Disease: Report of the TOSCA Study.
J Crohns Colitis
; 12(2): 188-196, 2018 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28961770
18.
Quantification of Th1 and Th17 Cells with Intracellular Staining Following PMA/Ionomycin Stimulation.
Curr Protoc Cytom
; 71: 6.35.1-6.35.7, 2015 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25559223
19.
Bone marrow-derived versus parenchymal sources of inducible nitric oxide synthase in experimental autoimmune encephalomyelitis.
J Neuroimmunol
; 150(1-2): 70-9, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15081250
20.
Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.
J Immunol
; 173(3): 1987-93, 2004 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15265933