Detalhe da pesquisa
1.
Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.
J Biol Chem
; 289(11): 7825-34, 2014 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24500713
2.
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
Bioorg Med Chem Lett
; 22(2): 1237-41, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22182498
3.
Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
J Pharmacol Exp Ther
; 336(2): 468-78, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21036913
4.
Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
Bioorg Med Chem Lett
; 21(22): 6888-94, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21986586
5.
Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.
Cancer Res
; 81(6): 1472-1485, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33414172
6.
KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.
Mol Pharmacol
; 76(1): 153-62, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19364813
7.
KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling.
Mol Cancer Ther
; 7(6): 1494-505, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566220
8.
KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
Mol Cancer Ther
; 7(5): 1054-65, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18483295
9.
Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC.
J Thorac Oncol
; 14(12): 2152-2163, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31470128
10.
Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor.
Bioorg Med Chem Lett
; 18(23): 6093-6, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954983
11.
Alpha-mercaptoketone based histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(24): 6482-5, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954984
12.
Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML).
PLoS One
; 11(3): e0152692, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27031987
13.
Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.
J Biomol Screen
; 20(10): 1232-45, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26265713
14.
SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Cancer Res
; 75(24): 5211-8, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26603897
15.
Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.
J Biomol Screen
; 19(8): 1201-11, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24870016
16.
Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2.
Clin Cancer Res
; 19(10): 2710-22, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23589174
17.
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
J Med Chem
; 53(21): 7739-55, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20931971
18.
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
J Med Chem
; 52(9): 3047-62, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19374401
19.
Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response.
Curr Chem Genomics
; 2: 1-9, 2008 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20161838
20.
XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.
Genes Dev
; 17(8): 977-90, 2003 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12672694