1.
Bioorg Med Chem Lett
; 17(1): 260-5, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17035019
RESUMO
A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.