Detalhe da pesquisa
1.
On the origin and evolution of the asteroid Ryugu: A comprehensive geochemical perspective.
Proc Jpn Acad Ser B Phys Biol Sci
; 98(6): 227-282, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35691845
2.
A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.
Chembiochem
; 13(15): 2191-5, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22965667
3.
Synthesis and structure-activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists.
Bioorg Med Chem
; 20(21): 6442-51, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010456
4.
Synthesis and evaluation of N-phenyl-(2-aminothiazol-4-yl)acetamides with phenoxypropanolamine moiety as selective ß3-adrenergic receptor agonists.
Chem Pharm Bull (Tokyo)
; 60(5): 647-58, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22689403
5.
Republication: Targeting PI3KC2ß Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours.
Anticancer Res
; 42(6): 3217-3230, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35641277
6.
Spectrally blue hydrated parent body of asteroid (162173) Ryugu.
Nat Commun
; 12(1): 5837, 2021 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34611167
7.
Synthesis and evaluation of novel phenylethanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.
Chem Pharm Bull (Tokyo)
; 58(4): 533-45, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20410638
8.
Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice.
Naunyn Schmiedebergs Arch Pharmacol
; 379(2): 191-9, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18762913
9.
Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.
Bioorg Med Chem
; 17(15): 5510-9, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19581100
10.
Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.
Bioorg Med Chem
; 17(9): 3283-94, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19362005
11.
Evaluation of the antidiabetic effects of dipeptidyl peptidase-IV inhibitor ASP8497 in streptozotocin-nicotinamide-induced mildly diabetic mice.
Pharmacology
; 83(3): 177-87, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176982
12.
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.
Cancer Res
; 67(12): 5840-50, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17575152
13.
Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo.
Naunyn Schmiedebergs Arch Pharmacol
; 377(3): 209-17, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18398600
14.
Targeting PI3KC2ß impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.
Anticancer Res
; 32(8): 3015-27, 2012 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22843869
15.
Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.
Eur J Med Chem
; 44(6): 2533-43, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19232786
16.
Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice.
Eur J Pharmacol
; 605(1-3): 170-6, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19171131
17.
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
Metabolism
; 58(3): 379-86, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217455
18.
Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors.
Pharmacol Rep
; 61(5): 899-908, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19904014
19.
ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity.
Biochem Pharmacol
; 76(1): 98-107, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18468582
20.
PIKfyve negatively regulates exocytosis in neurosecretory cells.
J Biol Chem
; 283(5): 2804-13, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18039667