Association of serum adiponectin with asthma and pulmonary function in the Japanese population.

Conflicting findings have been reported regarding the role of adiponectin in asthma. The aim of this study was to evaluate the association of adiponectin with pulmonary functions and asthma in the Japanese population. First, among a general population that participated in a previous study (group 1), we selected 329 subjects after excluding those with asthma, chronic obstructive pulmonary disease, and a smoking history and examined the associations of the serum total adiponectin levels with pulmonary functions. In a second cohort (group 2) consisting of 61 asthmatic patients and 175 control non-asthmatic subjects, we examined the associations between asthma and the levels of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms as well as the ratio of each isoform to total adiponectin level. Although the total adiponectin levels were not significantly different between the asthmatic and control subjects in group 2, the levels were significantly and positively associated with the forced expiratory volume in 1 s after adjustments for confounding factors (P < 0.05) in women in group 1. In group 2, the LMW adiponectin level was significantly higher and the MMW/total adiponectin ratio was significantly lower among the asthmatic subjects than among the control subjects after adjustments for confounding factors in both sexes (P < 0.05). The present study showed that a low total adiponectin level may lead to airway narrowing compatible with asthmatic airways in women, and higher LMW adiponectin levels and lower MMW/total adiponectin ratio are significantly associated with current asthma in both sexes.

The validity of nursery teachers' report on the physical activity of young children.

This study examined the validity of nursery teachers' report on the physical activity of young children. Subjects were twenty-one children aged 3 to 4 years (12 boys and 9 girls) at a nursery in Toyama Prefecture, Japan. Children were equipped with the Actiwatch (Mini-mitter Company Inc.) activity monitor and the Caloriecounter Select II (Kenz, Co, Ltd) for three consecutive weekdays to assess their daily physical activity levels. Nursery teachers completed a questionnaire containing questions on children's activity level during the measurement periods at the nursery. The results showed that subjects with a high frequency of physical activity were significantly associated with an increasing trend in total energy expenditure and activity counts per day. Children whose physical activity was rated as "very often" had a significantly higher activity level per day from the Actiwatch instrument, compared with peers whose physical activity was rated as "not often" (570.5 +/- 192.8 counts vs. 334.9 +/- 123.4 counts, p < 0.05). Regarding energy expenditure originating from physical activity and steps per day from the Caloriecounter, a significant difference was found between "very active" children and "inactive" children as rated by the nursery teachers (140.7 +/- 17.5 kcal vs. 78.2 +/- 17.4 kcal, p < 0.05; 16103 +/- 1896 steps vs. 10038 +/- 32 steps, p < 0.05). This study indicates that children's physical activity level as reported by their teachers in nursery surroundings is in accordance with the objective data from the Actiwatch and the Caloriecounter. The results suggest that nursery teachers' respondent for children in physical activity may be used as a valid measure to evaluate young children's physical activity levels, especially in nursery setting.

Validity of a questionnaire evaluating physical activity level in young children.

OBJECTIVE: To assess the validity of a questionnaire for evaluating the physical activity of young children as reported by parents. METHODS: Twenty-one male 1st grade elementary school children were the study subjects. The questionnaire contained 3 questions relating to the physical activity of children and was completed by their parents. These questions were: preference for physical activity: like very much, like, don't like; physical activity compared to peers: more than, the same as, less than peers; time spent on exercise activity per day: <30 min, 30-60 min, 60 min or more. We also assessed physical activity more objectively, using a small instrument for calculating total steps, energy expenditure originating from exercise, and total energy expenditure per day. The contribution of the questionnaire items to the objective indices was evaluated by linear regression analysis. RESULTS: Preference for physical activity was significantly associated with all the objective indices. Physical activity compared with peers had links with total energy expenditure. Time spent in activity was related to total steps and energy expenditure from exercise. CONCLUSION: All the questionnaire items were valid measures for evaluating the physical activity level in young children and could be applied to a large epidemiological survey.