Anatomical significance in aortoiliac occlusive disease.

Aortoiliac occlusive disease is a subset of peripheral arterial disease involving an atheromatous occlusion of the infrarenal aorta, common iliac arteries, or both. The disease, as it is known today, was described by the French surgeon René Leriche as a thrombotic occlusion of the end of the aorta. Leriche successfully linked the anatomic location of the occlusion with a unique triad of symptoms, including claudication, impotence, and decreased peripheral pulses. The anatomical location of the atheromatous lesions also has a direct influence on classification of the disease, as well as choice of treatment modality. Considering its impact on diagnosis and treatment, we aimed to provide a detailed understanding of the anatomical structures involved in aortoiliac occlusive disease. Familiarity with these structures will aid the physician in interpretation of radiologic images and surgical planning.

Deep learning based synthesis of MRI, CT and PET: Review and analysis.

Medical image synthesis represents a critical area of research in clinical decision-making, aiming to overcome the challenges associated with acquiring multiple image modalities for an accurate clinical workflow. This approach proves beneficial in estimating an image of a desired modality from a given source modality among the most common medical imaging contrasts, such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET). However, translating between two image modalities presents difficulties due to the complex and non-linear domain mappings. Deep learning-based generative modelling has exhibited superior performance in synthetic image contrast applications compared to conventional image synthesis methods. This survey comprehensively reviews deep learning-based medical imaging translation from 2018 to 2023 on pseudo-CT, synthetic MR, and synthetic PET. We provide an overview of synthetic contrasts in medical imaging and the most frequently employed deep learning networks for medical image synthesis. Additionally, we conduct a detailed analysis of each synthesis method, focusing on their diverse model designs based on input domains and network architectures. We also analyse novel network architectures, ranging from conventional CNNs to the recent Transformer and Diffusion models. This analysis includes comparing loss functions, available datasets and anatomical regions, and image quality assessments and performance in other downstream tasks. Finally, we discuss the challenges and identify solutions within the literature, suggesting possible future directions. We hope that the insights offered in this survey paper will serve as a valuable roadmap for researchers in the field of medical image synthesis.

Stylized Adversarial Defense.

Deep Convolution Neural Networks (CNNs) can easily be fooled by subtle, imperceptible changes to the input images. To address this vulnerability, adversarial training creates perturbation patterns and includes them in the training set to robustify the model. In contrast to existing adversarial training methods that only use class-boundary information (e.g., using a cross-entropy loss), we propose to exploit additional information from the feature space to craft stronger adversaries that are in turn used to learn a robust model. Specifically, we use the style and content information of the target sample from another class, alongside its class-boundary information to create adversarial perturbations. We apply our proposed multi-task objective in a deeply supervised manner, extracting multi-scale feature knowledge to create maximally separating adversaries. Subsequently, we propose a max-margin adversarial training approach that minimizes the distance between source image and its adversary and maximizes the distance between the adversary and the target image. Our adversarial training approach demonstrates strong robustness compared to state-of-the-art defenses, generalizes well to naturally occurring corruptions and data distributional shifts, and retains the model's accuracy on clean examples.

Deep Hypersphere Feature Regularization for Weakly Supervised RGB-D Salient Object Detection.

We propose a weakly supervised approach for salient object detection from multi-modal RGB-D data. Our approach only relies on labels from scribbles, which are much easier to annotate, compared with dense labels used in conventional fully supervised setting. In contrast to existing methods that employ supervision signals on the output space, our design regularizes the intermediate latent space to enhance discrimination between salient and non-salient objects. We further introduce a contour detection branch to implicitly constrain the semantic boundaries and achieve precise edges of detected salient objects. To enhance the long-range dependencies among local features, we introduce a Cross-Padding Attention Block (CPAB). Extensive experiments on seven benchmark datasets demonstrate that our method not only outperforms existing weakly supervised methods, but is also on par with several fully-supervised state-of-the-art models. Code is available at https://github.com/leolyj/DHFR-SOD.

Learning Enriched Features for Fast Image Restoration and Enhancement.

Given a degraded input image, image restoration aims to recover the missing high-quality image content. Numerous applications demand effective image restoration, e.g., computational photography, surveillance, autonomous vehicles, and remote sensing. Significant advances in image restoration have been made in recent years, dominated by convolutional neural networks (CNNs). The widely-used CNN-based methods typically operate either on full-resolution or on progressively low-resolution representations. In the former case, spatial details are preserved but the contextual information cannot be precisely encoded. In the latter case, generated outputs are semantically reliable but spatially less accurate. This paper presents a new architecture with a holistic goal of maintaining spatially-precise high-resolution representations through the entire network, and receiving complementary contextual information from the low-resolution representations. The core of our approach is a multi-scale residual block containing the following key elements: (a) parallel multi-resolution convolution streams for extracting multi-scale features, (b) information exchange across the multi-resolution streams, (c) non-local attention mechanism for capturing contextual information, and (d) attention based multi-scale feature aggregation. Our approach learns an enriched set of features that combines contextual information from multiple scales, while simultaneously preserving the high-resolution spatial details. Extensive experiments on six real image benchmark datasets demonstrate that our method, named as MIRNet-v2, achieves state-of-the-art results for a variety of image processing tasks, including defocus deblurring, image denoising, super-resolution, and image enhancement. The source code and pre-trained models are available at https://github.com/swz30/MIRNetv2.

Transformers in medical imaging: A survey.

Following unprecedented success on the natural language tasks, Transformers have been successfully applied to several computer vision problems, achieving state-of-the-art results and prompting researchers to reconsider the supremacy of convolutional neural networks (CNNs) as de facto operators. Capitalizing on these advances in computer vision, the medical imaging field has also witnessed growing interest for Transformers that can capture global context compared to CNNs with local receptive fields. Inspired from this transition, in this survey, we attempt to provide a comprehensive review of the applications of Transformers in medical imaging covering various aspects, ranging from recently proposed architectural designs to unsolved issues. Specifically, we survey the use of Transformers in medical image segmentation, detection, classification, restoration, synthesis, registration, clinical report generation, and other tasks. In particular, for each of these applications, we develop taxonomy, identify application-specific challenges as well as provide insights to solve them, and highlight recent trends. Further, we provide a critical discussion of the field's current state as a whole, including the identification of key challenges, open problems, and outlining promising future directions. We hope this survey will ignite further interest in the community and provide researchers with an up-to-date reference regarding applications of Transformer models in medical imaging. Finally, to cope with the rapid development in this field, we intend to regularly update the relevant latest papers and their open-source implementations at https://github.com/fahadshamshad/awesome-transformers-in-medical-imaging.

Deeply Supervised Discriminative Learning for Adversarial Defense.

Deep neural networks can easily be fooled by an adversary with minuscule perturbations added to an input image. The existing defense techniques suffer greatly under white-box attack settings, where an adversary has full knowledge of the network and can iterate several times to find strong perturbations. We observe that the main reason for the existence of such vulnerabilities is the close proximity of different class samples in the learned feature space of deep models. This allows the model decisions to be completely changed by adding an imperceptible perturbation to the inputs. To counter this, we propose to class-wise disentangle the intermediate feature representations of deep networks, specifically forcing the features for each class to lie inside a convex polytope that is maximally separated from the polytopes of other classes. In this manner, the network is forced to learn distinct and distant decision regions for each class. We observe that this simple constraint on the features greatly enhances the robustness of learned models, even against the strongest white-box attacks, without degrading the classification performance on clean images. We report extensive evaluations in both black-box and white-box attack scenarios and show significant gains in comparison to state-of-the-art defenses.

Regularization of deep neural networks with spectral dropout.

The big breakthrough on the ImageNet challenge in 2012 was partially due to the 'Dropout' technique used to avoid overfitting. Here, we introduce a new approach called 'Spectral Dropout' to improve the generalization ability of deep neural networks. We cast the proposed approach in the form of regular Convolutional Neural Network (CNN) weight layers using a decorrelation transform with fixed basis functions. Our spectral dropout method prevents overfitting by eliminating weak and 'noisy' Fourier domain coefficients of the neural network activations, leading to remarkably better results than the current regularization methods. Furthermore, the proposed is very efficient due to the fixed basis functions used for spectral transformation. In particular, compared to Dropout and Drop-Connect, our method significantly speeds up the network convergence rate during the training process (roughly ×2), with considerably higher neuron pruning rates (an increase of ∼30%). We demonstrate that the spectral dropout can also be used in conjunction with other regularization approaches resulting in additional performance gains.

Image Super-Resolution as a Defense Against Adversarial Attacks.

Convolutional Neural Networks have achieved significant success across multiple computer vision tasks. However, they are vulnerable to carefully crafted, human-imperceptible adversarial noise patterns which constrain their deployment in critical security-sensitive systems. This paper proposes a computationally efficient image enhancement approach that provides a strong defense mechanism to effectively mitigate the effect of such adversarial perturbations. We show that deep image restoration networks learn mapping functions that can bring off-the-manifold adversarial samples onto the natural image manifold, thus restoring classification towards correct classes. A distinguishing feature of our approach is that, in addition to providing robustness against attacks, it simultaneously enhances image quality and retains models performance on clean images. Furthermore, the proposed method does not modify the classifier or requires a separate mechanism to detect adversarial images. The effectiveness of the scheme has been demonstrated through extensive experiments, where it has proven a strong defense in gray-box settings. The proposed scheme is simple and has the following advantages: (1) it does not require any model training or parameter optimization, (2) it complements other existing defense mechanisms, (3) it is agnostic to the attacked model and attack type and (4) it provides superior performance across all popular attack algorithms. Our codes are publicly available at https://github.com/aamir-mustafa/super-resolution-adversarial-defense.

Response to "Ghost Numbers".

This note clarifies the experimental settings of [1] and shows that the issue raised by [2] is due to a lack of details in [1] which resulted in a misinterpretation of the experimental settings.

Cost-Sensitive Learning of Deep Feature Representations From Imbalanced Data.

Class imbalance is a common problem in the case of real-world object detection and classification tasks. Data of some classes are abundant, making them an overrepresented majority, and data of other classes are scarce, making them an underrepresented minority. This imbalance makes it challenging for a classifier to appropriately learn the discriminating boundaries of the majority and minority classes. In this paper, we propose a cost-sensitive (CoSen) deep neural network, which can automatically learn robust feature representations for both the majority and minority classes. During training, our learning procedure jointly optimizes the class-dependent costs and the neural network parameters. The proposed approach is applicable to both binary and multiclass problems without any modification. Moreover, as opposed to data-level approaches, we do not alter the original data distribution, which results in a lower computational cost during the training process. We report the results of our experiments on six major image classification data sets and show that the proposed approach significantly outperforms the baseline algorithms. Comparisons with popular data sampling techniques and CoSen classifiers demonstrate the superior performance of our proposed method.

A Discriminative Representation of Convolutional Features for Indoor Scene Recognition.

Indoor scene recognition is a multi-faceted and challenging problem due to the diverse intra-class variations and the confusing inter-class similarities that characterize such scenes. This paper presents a novel approach that exploits rich mid-level convolutional features to categorize indoor scenes. Traditional convolutional features retain the global spatial structure, which is a desirable property for general object recognition. We, however, argue that the structure-preserving property of the convolutional neural network activations is not of substantial help in the presence of large variations in scene layouts, e.g., in indoor scenes. We propose to transform the structured convolutional activations to another highly discriminative feature space. The representation in the transformed space not only incorporates the discriminative aspects of the target data set but also encodes the features in terms of the general object categories that are present in indoor scenes. To this end, we introduce a new large-scale data set of 1300 object categories that are commonly present in indoor scenes. Our proposed approach achieves a significant performance boost over the previous state-of-the-art approaches on five major scene classification data sets.

Deep Reconstruction Models for Image Set Classification.

Image set classification finds its applications in a number of real-life scenarios such as classification from surveillance videos, multi-view camera networks and personal albums. Compared with single image based classification, it offers more promises and has therefore attracted significant research attention in recent years. Unlike many existing methods which assume images of a set to lie on a certain geometric surface, this paper introduces a deep learning framework which makes no such prior assumptions and can automatically discover the underlying geometric structure. Specifically, a Template Deep Reconstruction Model (TDRM) is defined whose parameters are initialized by performing unsupervised pre-training in a layer-wise fashion using Gaussian Restricted Boltzmann Machines (GRBMs). The initialized TDRM is then separately trained for images of each class and class-specific DRMs are learnt. Based on the minimum reconstruction errors from the learnt class-specific models, three different voting strategies are devised for classification. Extensive experiments are performed to demonstrate the efficacy of the proposed framework for the tasks of face and object recognition from image sets. Experimental results show that the proposed method consistently outperforms the existing state of the art methods.

A very unusual complication of amniocentesis.

The uses of amniocentesis are numerous, including determination of chromosomal abnormalities, lung maturity, and infections. A common complication of amniocentesis is loss of the pregnancy, but rare complications should be considered. The role of patient history and clinical observation of uncommon presentations are critical in the management of the patient.