1.
Org Lett
; 9(26): 5617-20, 2007 Dec 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18041848
RESUMO
Recently developed copper-catalyzed coupling methodology has been applied to the synthesis of amino acid derived enamides. Bond formation proved to be strongly influenced by protection strategy and vinyl iodide substitution while tolerant of limited side chain functionality. Assessment of aminopeptidase activity revealed a preference for (E)-1,2-disubstituted constructs.