Detalhe da pesquisa
1.
High-throughput screening for phosphatidylserine decarboxylase inhibitors using a distyrylbenzene-bis-aldehyde (DSB-3)-based fluorescence assay.
J Biol Chem
; 294(32): 12146-12156, 2019 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31227523
2.
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Bioorg Med Chem
; 25(2): 496-513, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914948
3.
Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
J Pharmacol Exp Ther
; 356(2): 293-304, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26582730
4.
Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.
J Pharmacol Exp Ther
; 354(3): 340-9, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26109678
5.
In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10).
J Neurochem
; 129(2): 275-83, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24266811
6.
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors.
Bioorg Med Chem Lett
; 22(12): 4153-8, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22579422
7.
Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore.
Oncotarget
; 12(9): 891-906, 2021 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33953843
8.
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Eur J Pharmacol
; 799: 16-25, 2017 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28132910
9.
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia.
PLoS One
; 11(7): e0159996, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27467081
10.
Signal discrimination in the semicircular canals: a role for group I metabotropic glutamate receptors.
Neuroreport
; 13(14): 1765-8, 2002 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12395119
11.
Transmitter release from Rana pipiens vestibular hair cells via mGluRs: a role for intracellular Ca(++) release.
Hear Res
; 172(1-2): 99-109, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12361872
12.
Development of a high-throughput calcium flux assay for identification of all ligand types including positive, negative, and silent allosteric modulators for G protein-coupled receptors.
Assay Drug Dev Technol
; 10(5): 457-67, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22746835
13.
Evaluation and optimization of compound solubilization and delivery methods in a two-tiered ion channel lead optimization triage.
Assay Drug Dev Technol
; 10(2): 202-11, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22085018
14.
Design of an automated enhanced-throughput platform for functional characterization of positive allosteric modulator-induced leftward shifts in apparent agonist potency in vitro.
J Lab Autom
; 17(2): 104-15, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357567
15.
A fluorescence-based high-throughput screening assay for the identification of T-type calcium channel blockers.
Assay Drug Dev Technol
; 7(3): 266-80, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19530894
16.
Aberrant synaptic activation of N-methyl-D-aspartate receptors underlies ethanol withdrawal hyperexcitability.
J Pharmacol Exp Ther
; 321(1): 60-72, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17229881
17.
Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure.
Alcohol Clin Exp Res
; 30(2): 368-76, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16441286
18.
Actions of acute and chronic ethanol on presynaptic terminals.
Alcohol Clin Exp Res
; 30(2): 222-32, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16441271
19.
Dual synaptic sites of D(1)-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens.
Synapse
; 58(1): 30-44, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16037948
20.
Ethanol alters the frequency, amplitude, and decay kinetics of Sr2+-supported, asynchronous NMDAR mEPSCs in rat hippocampal slices.
J Neurophysiol
; 91(6): 2568-77, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-14749312