RESUMO
OBJECTIVE: To evaluate the association between BC and urinary concentrations of free-bisphenol A (BPA-F), the biological form of BPA, among women residing in Northern Mexico. METHODS: The population under study comprised 394 histologically confirmed BC cases and 404 age-matched controls. Women were interviewed face to face about their sociodemographic and reproductive characteristics. BPA-F was determined by high-pressure liquid chromatography equipped with a fluorescence detector (HPLC/FLD). Logistic regression models were used to estimate the adjusted BC risk in relation to BPA-F. RESULTS: BPA-F geometric mean was significantly higher among cases compared to controls (3.16 µg/L in cases and 2.47 µg/L in controls). A significant adjusted BC odds ratio of 2.31 (95% CI: 1.43-3.74) was estimated for the highest category of BPA-F compared to the lowest category. CONCLUSION: BPA-F may be an environmental cofactor of BC. Since this is the first report on BPA-F association with BC, our results need to be replicated.
Assuntos
Compostos Benzidrílicos/efeitos adversos , Neoplasias da Mama/induzido quimicamente , Exposição Ambiental/efeitos adversos , Fenóis/efeitos adversos , Adolescente , Adulto , Idoso , Compostos Benzidrílicos/urina , Neoplasias da Mama/epidemiologia , Estudos de Casos e Controles , Exposição Ambiental/análise , Feminino , Humanos , Entrevistas como Assunto , México/epidemiologia , Pessoa de Meia-Idade , Fenóis/urina , Adulto JovemRESUMO
Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, which has been previously linked to diabetes among non-Hispanic populations. As part of a case control study for breast cancer, only controls with BPA information were included in this report. The final sample size comprises 70 self-reported diabetics and 334 non-diabetics. Urinary free bisphenol A (BPA-F) (µg/L) was determined by solid-phase extraction and HPLC/FLD analysis. Logistic regression models were used to evaluate the association between BPA-F and self-reported diabetes. After adjusting by age, urinary BPA-F (4.06-224.53 µg/g creatinine) was associated with diabetes exposure (OR = 1.85; 95% CI 1.04, 3.28) compared with women in the reference category (0.67-4.05 µg/g creatinine). BPA may be an environmental cofactor of diabetes. More studies are needed to confirm this result, especially in Hispanic populations.