Detalhe da pesquisa
1.
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes.
Proc Natl Acad Sci U S A
; 118(20)2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33990469
2.
Effector membrane translocation biosensors reveal G protein and ßarrestin coupling profiles of 100 therapeutically relevant GPCRs.
Elife
; 112022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35302493
3.
Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction.
ACS Pharmacol Transl Sci
; 5(10): 892-906, 2022 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36268126
4.
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization.
Nat Cell Biol
; 6(1): 52-8, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14688793
5.
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.
Circ Heart Fail
; 14(3): e007351, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33663236
6.
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.
JACC Basic Transl Sci
; 6(8): 676-689, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34466754
7.
Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor.
ACS Med Chem Lett
; 10(1): 67-73, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655949
8.
Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment.
JACC Basic Transl Sci
; 4(8): 905-920, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31909300
9.
Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor.
J Med Chem
; 50(6): 1401-8, 2007 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17319653
10.
Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.
Neuropharmacology
; 102: 59-71, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522434
11.
Comparing label-free biosensors for pharmacological screening with cell-based functional assays.
Assay Drug Dev Technol
; 8(2): 219-27, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20085460
12.
Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1.
J Biol Chem
; 282(43): 31610-20, 2007 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17785463
13.
Assembly and signaling of CRLR and RAMP1 complexes assessed by BRET.
Biochemistry
; 46(23): 7022-33, 2007 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-17503773