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1.
Gastrointest Endosc ; 68(3): 440-6, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18423466

RESUMO

BACKGROUND: Despite different forms of treatment, few studies have been performed on the outcome and prognosis of patients admitted to the hospital because of gastric vascular ectasia (GVE) and upper-GI bleeding (UGIB). There is also little knowledge on the efficacy of argon plasma coagulation (APC) in different subgroups of GVE lesions. OBJECTIVE: This study was designed to evaluate the efficacy of APC in patients admitted to the hospital with UGIB because of GVE. DESIGN: Prospective evaluation of consecutive cases of UGIB because of GVE. SETTING: Tertiary and university-affiliated hospital. PATIENTS AND INTERVENTIONS: Twenty-nine patients were included and divided into 3 subgroups: focal vascular ectasia lesions (FVE) (n = 10), portal hypertensive gastropathy (PHG) (n = 11), and gastric antral vascular ectasia (GAVE) (n = 8). Patients were followed at 3 months and every 6 months thereafter during a mean of 23.1 months (range 18-37 months). All patients received intensive APC treatment that was repeated, depending on the endoscopic appearance or clinical evaluation. RESULTS: The overall success of APC treatment was 86%, with only one recurrence of UGIB during the follow-up period. The number of APC sessions was 1.2, 2.2, and 2.3, in each subgroup (not significant), with a total number of sessions of 1.9 +/- 1.3. Treatment success was 90% in the FVE group, 81% in the PHG group, and 87.5% in the GAVE group (NS). The rise in hematocrit from baseline values in the overall group and in each subgroup was significant (P > .01). LIMITATIONS: A single-center study and small sample. CONCLUSIONS: Endoscopic thermal ablation with APC is effective in managing UGIB and in reducing transfusion requirements in patients admitted for GI hemorrhage because of different endoscopic types of GVE.


Assuntos
Ectasia Vascular Gástrica Antral/cirurgia , Hemorragia Gastrointestinal/cirurgia , Gastroscopia , Fotocoagulação a Laser/métodos , Doença Aguda , Idoso , Idoso de 80 Anos ou mais , Argônio/uso terapêutico , Educação Médica Continuada , Serviço Hospitalar de Emergência , Feminino , Seguimentos , Ectasia Vascular Gástrica Antral/complicações , Ectasia Vascular Gástrica Antral/patologia , Mucosa Gástrica/patologia , Hemorragia Gastrointestinal/etiologia , Hemorragia Gastrointestinal/patologia , Humanos , Fotocoagulação a Laser/efeitos adversos , Masculino , Pessoa de Meia-Idade , Probabilidade , Estudos Prospectivos , Medição de Risco , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Espanha , Resultado do Tratamento
2.
Gastroenterol Hepatol ; 30(2): 66-8, 2007 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-17335712

RESUMO

The use of herbal medicines believed to have therapeutic properties is becoming increasingly widespread. These medicines are usually taken by patients on their own initiative and physicians are often unaware of which patients are taking these substances. Herbal medicines can be taken in the form of teas, powders, and liquid extracts. In the last few years, it has come to light that these natural remedies are not free of risks, especially the risk of interaction with other drugs or hepatotoxicity, ranging from asymptomatic forms to massive hepatic necrosis. We describe a series of 5 patients notified to the Spanish Pharmacovigilance System of medicinal products for human use. All the patients developed acute hepatitis during Colpachi treatment lasting several months, which resolved after discontinuing intake of this substance. Systematic examination of the literature revealed the existence of 6 other reported cases of suspected Colpachi-induced hepatotoxicity.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas/etiologia , Croton/efeitos adversos , Fitoterapia/efeitos adversos , Preparações de Plantas/efeitos adversos , Plantas Medicinais/efeitos adversos , Doença Aguda , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
4.
Rev. colomb. bioet ; 8(1): 123-143, 2013.
Artigo em Espanhol | Bioeticacol | ID: bic-4254

RESUMO

El artículo analiza ciertos dilemas éticos que plantea el procedimiento de Diagnóstico preimplantatorio a partir de la óptica de la bioética a través de un análisis documental, doctrinario y normativo. Luego de una introducción al problema, se aborda brevemente la situación legislativa en distintos países, tomados cada uno como ejemplos de los modelos existentes, para proceder con posterioridad a la revisión de las distintas controversias éticas que plantea el procedimiento, en sus distintas variantes. Concluyendo el trabajo con la toma de postura acerca de cuál pareciera el modelo legislativo más adecuado a seguir.(AU)


The present article analyses certain ethical dilemmas that the preimplantation diagnosis procedure raises from the bioethical view through a documental, doctrinarian and legal analysis. Following an introduction to the problem, the legislative situation in different countries is briefly addressed, taken each one as an example of existing models, in order to proceed afterwards into the review of the different ethical controversies that the procedure raises in its variants. The study is concluded by taking a stand regarding which appears to be the most adequate legislative model to follow.(AU)


Assuntos
Bioética , Diagnóstico Pré-Natal , Diagnóstico Pré-Implantação , Eugenia (Ciência) , Testes Genéticos
5.
Rev. colomb. bioét ; 8(1): 123-143, ene.-jun. 2013.
Artigo em Espanhol | LILACS | ID: lil-750268

RESUMO

El artículo analiza ciertos dilemas éticos que plantea el procedimiento de Diagnóstico preimplantatorio a partir de la óptica de la bioética a través de un análisis documental, doctrinario y normativo. Luego de una introducción al problema, se aborda brevemente la situación legislativa en distintos países, tomados cada uno como ejemplos de los modelos existentes, para proceder con posterioridad a la revisión de las distintas controversias éticas que plantea el procedimiento, en sus distintas variantes. Concluyendo el trabajo con la toma de postura acerca de cuál pareciera el modelo legislativo más adecuado a seguir.


The present article analyses certain ethical dilemmas that the preimplantation diagnosis procedure raises from the bioethical view through a documental, doctrinarian and legal analysis. Following an introduction to the problem, the legislative situation in different countries is briefly addressed, taken each one as an example of existing models, in order to proceed afterwards into the review of the different ethical controversies that the procedure raises in its variants. The study is concluded by taking a stand regarding which appears to be the most adequate legislative model to follow.


Assuntos
Bioética , Eugenia (Ciência) , Testes Genéticos , Diagnóstico Pré-Implantação , Diagnóstico Pré-Natal
6.
Vet. Méx ; 39(3): 269-277, jul.-sep. 2008. graf, tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: lil-632885

RESUMO

The effect of semi-synthetic steroid trenbolone acetate (TBA) on the ornamental fish Poecilia reticulata (guppy) was studied. The steroid at a dose of 300 mg/kg feed was administered to 30 days old juvenile specimens during 60 days. Forty days after treatment was ended, an evaluation aimed to determine the steroid residual effect was undertaken. Survival, masculinization ratio and the drug anabolic effect were analyzed. Results showed TBA to be effective to induce masculinization, differing (P < 0.001) with the control group, which registered 32% males and 68% females. TBA turned out to be an excellent anabolic as well, since treated fish showed weight increase, a larger body and an increased size of caudal fin. The steroid did not cause any damage on the treated population. The survival factor was 93.3% for the treated fish as compared to 83% for the control group.


Se investigó el efecto del esteroide semisintético acetato de trembolona (ATB) en el pez de ornato Poecilia reticulata (guppy). Especímenes juveniles de 30 días de edad fueron tratados con el esteroide a dosis de 300 mg/kg de alimento durante 60 días. Al término del tratamiento, 40 días después, se estimó el efecto residual del esteroide. Se analizó la sobrevivencia, la proporción de peces masculinizados, así como el efecto anabólico. Los resultados indicaron que el ATB es eficaz para inducir la masculinización, a diferencia del grupo testigo, donde se registraron 32% de machos. Asimismo, el ATB tuvo un efecto anabólico, ya que los peces tratados mostraron mayor peso y talla e incremento de la aleta caudal. El esteroide no causó daño en la población tratada, al sobrevivir 93.3% de los peces, comparado con 83% del grupo testigo.

7.
Vet. Méx ; 39(4): 387-395, oct.-dic. 2008. tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: lil-632890

RESUMO

The objective of this study was to describe alterations in blood clinical biochemistry and urinalysis which enable to establish the diagnosis of diabetes mellitus in dogs. Thirty cases of diabetic dogs were analyzed. The inclusion criteria were the following: hyperglycemia above 14 mmol/L, glucosuria, urine density above 1.014 and polyuria-polydipsia. Dogs of different breeds, from 7 months to 14 years of age and both genders (73.3% females and 26.7% males) were studied. The most frequent biochemical alterations in blood serum were: hyperglycemia (100%), increased urea (46%) and creatinine (13%), increase of enzyme activities ALT (50%), AST (46%), alkaline phosphatase (56%), amylase (20%), creatine kinase (66%); hypercholesterolemia (66%), hyperglobulinemia (33%), hyperphosphoremia (33%), hyperkaliemia (43%), hyponatremia (16%), hypochloremia (46%), hypobicarbonatemia (50%), increased anion gap (53%), increased strong ion difference (30%), increased serum osmolality (23%) and hypertriglyceridemia (50%). The urine density was between 1.015 and 1.064, mean value of urine glucose 49 mmol/L. Urine ketone bodies were detected in 10% of all cases. Described alterations in clinical biochemistry are important for the diagnosis, clinical care, and prognosis of dogs with diabetes mellitus.


El objetivo de este estudio fue describir alteraciones en la bioquímica clínica sanguínea y en el urianálisis, con el fin de establecer un diagnóstico integral en perros con diabetes mellitus. Se analizaron 30 casos de perros diabéticos. Los criterios de inclusión fueron: hiperglucemia superior a 14 mmol/L, glucosuria, densidad urinaria superior a 1.014 y poliuria-polidipsia. Los perros fueron de diferentes razas, de siete meses a 14 años de edad y de ambos géneros (73.3% hembras y 26.7% machos). Las frecuencias de las principales alteraciones bioquímicas en suero fueron: hiperglucemia (100.0%), incremento en las concentraciones de urea (46%) y de creatinina (13%), incremento de la actividad de las enzimas ALT (50%), AST (46%), fosfatasa alcalina (56%), amilasa (20%), creatina cinasa (66%), hipercolestrolemia (66%), hiperglobulinemia (33%), hiperfosforemia (33%), hipercaliemia (43%), hiponatremia (16%), hipocloremia (46%), hipobicarbonatemia (50%), aumento de ácidos no volátiles (53%), incremento en la diferencia de iones fuertes (30%), hiperosmolalidad (23%) e hipertrigliceridemia (50%). La densidad urinaria osciló entre 1.015 y 1.064, la glucosuria presentó, en promedio, 49 mmol/L. En 10% de los casos se observó cetonuria. Las alteraciones descritas en la bioquímica clínica son importantes para el diagnóstico, manejo clínico y pronóstico de los perros con diabetes mellitus.

9.
Gastroenterol. hepatol. (Ed. impr.) ; 30(2): 66-68, feb. 2007. tab
Artigo em Es | IBECS (Espanha) | ID: ibc-052459

RESUMO

El uso de hierbas medicinales con supuesta actividad terapéutica está creciendo. Estas medicinas las suele tomar el paciente por propia iniciativa y, a menudo, con desconocimiento por parte de su médico. Se pueden tomar en forma de infusiones o extractos líquidos. En los últimos años se ha ido conociendo que estos remedios naturales no están exentos de riesgo, especialmente riesgo de interacción con otras medicaciones o hepatotoxicidad que puede variar desde formas asintomáticas a necrosis hepática masiva. Describimos 5 pacientes notificados al Sistema Español de Farmacovigilancia de productos medicinales de uso humano. Todos los pacientes desarrollaron hepatitis aguda durante el tratamiento con Colpachi durante varios meses, que se resolvió al parar la toma de esta sustancia. La revisión sistemática de la literatura revela la existencia de otras 6 notificaciones de hepatotoxicidad inducida por Colpachi


The use of herbal medicines believed to have therapeutic properties is becoming increasingly widespread. These medicines are usually taken by patients on their own initiative and physicians are often unaware of which patients are taking these substances. Herbal medicines can be taken in the form of teas, powders, and liquid extracts. In the last few years, it has come to light that these natural remedies are not free of risks, especially the risk of interaction with other drugs or hepatotoxicity, ranging from asymptomatic forms to massive hepatic necrosis. We describe a series of 5 patients notified to the Spanish Pharmacovigilance System of medicinal products for human use. All the patients developed acute hepatitis during Colpachi treatment lasting several months, which resolved after discontinuing intake of this substance. Systematic examination of the literature revealed the existence of 6 other reported cases of suspected Colpachi-induced hepatotoxicity


Assuntos
Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Humanos , Extratos Vegetais/efeitos adversos , Plantas Medicinais/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Doença Aguda
10.
Vet. Méx ; 25(4): 313-21, oct.-dic. 1994. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-187986

RESUMO

Se evaluó la rentabilidad de cerdos en una economía de traspatio en Axochiapan, Morelos, en 1990. Se proponen tres dietas balanceadas de bajo costo, eficientes y conformadas con ingredientes de la zona; tomando como punto de referencia el crecimiento de los animales con albaméx. El diseño experimental incluía 24 cerdos con peso inicial de 30 kilogramos, divididos en cuatro tratamientos; quincenalmente se registró el peso y la talla por animal, así como los costos de la evaluación. El análisis se realizó como un modelo que relaciona el peso en función del tiempo, evaluando su fidelidad por el análisis de residuos. Los resultados indican que los modelos explican el comportamiento de los cerdos. El crecimiento de los mismos, alimentados con Albamex fue superior a las otras dietas. La dieta 2 es la más eficiente, de acuerdo con la ponderación de crecimiento y costo, siguiéndole en eficiencia la dieta 1. El costo de operación por alimento en Albamex fue de 71.2 por ciento, mientaras que la dieta 1 tuvo la menor proporción, con 54.83 por ciento. El costo por tonelada de alimento fluctuó entre $ 903,750.00 y $ 453,690.00 respectivamente. La evaluación confirma que en una economía de traspatio, el alimento comercial no es conveniente


Assuntos
Animais , Suínos/crescimento & desenvolvimento , Dieta/veterinária , Fenômenos Fisiológicos da Nutrição Animal , Economia dos Alimentos
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