Pesquisa | Biblioteca Virtual em Saúde

1.

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia.

Goswami, Swagata; Mani, Rajeswaran; Nunes, Jessica; Chiang, Chi-Ling; Zapolnik, Kevan; Hu, Eileen; Frissora, Frank; Mo, Xiaokui; Walker, Logan A; Yan, Pearlly; Bundschuh, Ralf; Beaver, Larry; Devine, Raymond; Tsai, Yo-Ting; Ventura, Ann; Xie, Zhiliang; Chen, Min; Lapalombella, Rosa; Walker, Alison; Mims, Alice; Larkin, Karilyn; Grieselhuber, Nicole; Bennett, Chad; Phelps, Mitch; Hertlein, Erin; Behbehani, Gregory; Vasu, Sumithira; Byrd, John C; Muthusamy, Natarajan.

Blood ; 139(9): 1340-1358, 2022 03 03.

Artigo em Inglês | MEDLINE | ID: mdl-34788382

2.

DNA Origami Nanostructures Elicit Dose-Dependent Immunogenicity and Are Nontoxic up to High Doses In Vivo.

Lucas, Christopher R; Halley, Patrick D; Chowdury, Amjad A; Harrington, Bonnie K; Beaver, Larry; Lapalombella, Rosa; Johnson, Amy J; Hertlein, Erin K; Phelps, Mitch A; Byrd, John C; Castro, Carlos E.

Small ; 18(26): e2108063, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35633287

3.

Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells.

Do, Priscilla; Beckwith, Kyle A; Cheney, Carolyn; Tran, Minh; Beaver, Larry; Griffin, Brittany G; Mo, Xiaokui; Liu, Yang; Lapalombella, Rosa; Hertlein, Erin; Muthusamy, Natarajan; Byrd, John C.

J Immunol ; 202(9): 2806-2816, 2019 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-30910862

4.

TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia.

Balatti, Veronica; Rizzotto, Lara; Miller, Cecelia; Palamarchuk, Alexey; Fadda, Paolo; Pandolfo, Rosantony; Rassenti, Laura Z; Hertlein, Erin; Ruppert, Amy S; Lozanski, Arletta; Lozanski, Gerard; Kipps, Thomas J; Byrd, John C; Croce, Carlo M; Pekarsky, Yuri.

Proc Natl Acad Sci U S A ; 112(7): 2169-74, 2015 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-25646413

5.

OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells.

Liu, Ta-Ming; Ling, Yonghua; Woyach, Jennifer A; Beckwith, Kyle; Yeh, Yuh-Ying; Hertlein, Erin; Zhang, Xiaoli; Lehman, Amy; Awan, Farrukh; Jones, Jeffrey A; Andritsos, Leslie A; Maddocks, Kami; MacMurray, Jessica; Salunke, Santosh B; Chen, Ching-Shih; Phelps, Mitch A; Byrd, John C; Johnson, Amy J.

Blood ; 125(2): 284-95, 2015 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-25293770

6.

FcÎ³ receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies.

Justiniano, Steven E; Elavazhagan, Saranya; Fatehchand, Kavin; Shah, Prexy; Mehta, Payal; Roda, Julie M; Mo, Xiaokui; Cheney, Carolyn; Hertlein, Erin; Eubank, Timothy D; Marsh, Clay; Muthusamy, Natarajan; Butchar, Jonathan P; Byrd, John C; Tridandapani, Susheela.

J Biol Chem ; 288(37): 26800-9, 2013 Sep 13.

Artigo em Inglês | MEDLINE | ID: mdl-23902770

7.

NF-κB p50 (nfkb1) contributes to pathogenesis in the Eµ-TCL1 mouse model of chronic lymphocytic leukemia.

Chen, Timothy L; Tran, Minh; Lakshmanan, Aparna; Harrington, Bonnie K; Gupta, Nikhil; Goettl, Virginia M; Lehman, Amy M; Trudeau, Stephen; Lucas, David M; Johnson, Amy J; Byrd, John C; Hertlein, Erin.

Blood ; 130(3): 376-379, 2017 07 20.

Artigo em Inglês | MEDLINE | ID: mdl-28515090

8.

Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia.

Fobare, Sydney; Elgamal, Ola A; Wunderlich, Mark; Stahl, Emily; Mehmood, Abeera; Furby, Casie; Lerma, James R; Sesterhenn, Thomas M; Pan, Jianmin; Rai, Jayesh; Johnstone, Megan E; Abdul-Aziz, Amina; Johnson, Mariah L; Rai, Shesh N; Byrd, John C; Hertlein, Erin.

Cancers (Basel) ; 16(3)2024 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-38339323

9.

Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia.

Elgamal, Ola A; Fobare, Sydney; Vibhute, Sandip; Mehmood, Abeera; Vroom, Dennis C; Johnson, Mariah L; Stearns, Blaise; Lerma, James R; Truxall, Jean; Stahl, Emily; Carmichael, Bridget; Orwick, Shelley J; Mims, Alice S; Curran, Emily; Santhanam, Ramasamy; Tridandapani, Susheela; Phelps, Mitch A; Xie, Zhiliang; Coss, Christopher C; Baker, Sharyn D; Patrick, Jeffrey; Ezzell, Janel K; Rai, Jayesh; Pan, Jianmin; Rai, Shesh N; Stillwell, Cody; Wunderlich, Mark; Abdulrahim, Mouad; Goodwin, Thomas E; Hilinski, Gerard; Bennett, Chad E; Hertlein, Erin; Byrd, John C.

JCI Insight ; 9(8)2024 Apr 22.

Artigo em Inglês | MEDLINE | ID: mdl-38646934

10.

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

Herman, Sarah E M; Gordon, Amber L; Hertlein, Erin; Ramanunni, Asha; Zhang, Xiaoli; Jaglowski, Samantha; Flynn, Joseph; Jones, Jeffrey; Blum, Kristie A; Buggy, Joseph J; Hamdy, Ahmed; Johnson, Amy J; Byrd, John C.

Blood ; 117(23): 6287-96, 2011 Jun 09.

Artigo em Inglês | MEDLINE | ID: mdl-21422473

11.

Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma.

Alinari, Lapo; Yu, Bo; Christian, Beth A; Yan, Fengting; Shin, Jungook; Lapalombella, Rosa; Hertlein, Erin; Lustberg, Mark E; Quinion, Carl; Zhang, Xiaoli; Lozanski, Gerard; Muthusamy, Natarajan; Prætorius-Ibba, Mette; O'Connor, Owen A; Goldenberg, David M; Byrd, John C; Blum, Kristie A; Baiocchi, Robert A.

Blood ; 117(17): 4530-41, 2011 Apr 28.

Artigo em Inglês | MEDLINE | ID: mdl-21228331

12.

Mass Cytometry as a Tool for Investigating Senescence in Multiple Model Systems.

Abdul-Aziz, Amina; Devine, Raymond D; Lyberger, Justin M; Chang, Hsiaochi; Kovacs, Amy; Lerma, James R; Rogers, Andrew M; Byrd, John C; Hertlein, Erin; Behbehani, Gregory K.

Cells ; 12(16)2023 08 11.

Artigo em Inglês | MEDLINE | ID: mdl-37626855

13.

Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells.

Hertlein, Erin; Triantafillou, Georgia; Sass, Ellen J; Hessler, Joshua D; Zhang, Xiaoli; Jarjoura, David; Lucas, David M; Muthusamy, Natarajan; Goldenberg, David M; Lee, Robert J; Byrd, John C.

Blood ; 116(14): 2554-8, 2010 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-20574049

14.

17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition.

Hertlein, Erin; Wagner, Amy J; Jones, Jeffrey; Lin, Thomas S; Maddocks, Kami J; Towns, William H; Goettl, Virginia M; Zhang, Xiaoli; Jarjoura, David; Raymond, Chelsey A; West, Derek A; Croce, Carlo M; Byrd, John C; Johnson, Amy J.

Blood ; 116(1): 45-53, 2010 Jul 08.

Artigo em Inglês | MEDLINE | ID: mdl-20351313

15.

Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia.

Chen, Shih-Shih; Raval, Aparna; Johnson, Amy J; Hertlein, Erin; Liu, Te-Hui; Jin, Victor X; Sherman, Mara H; Liu, Shu-Jun; Dawson, David W; Williams, Katie E; Lanasa, Mark; Liyanarachchi, Sandya; Lin, Thomas S; Marcucci, Guido; Pekarsky, Yuri; Davuluri, Ramana; Croce, Carlo M; Guttridge, Denis C; Teitell, Michael A; Byrd, John C; Plass, Christoph.

Proc Natl Acad Sci U S A ; 106(32): 13433-8, 2009 Aug 11.

Artigo em Inglês | MEDLINE | ID: mdl-19666576

16.

TP-0903 Is Active in Preclinical Models of Acute Myeloid Leukemia with TP53 Mutation/Deletion.

Eisenmann, Eric D; Stromatt, Jack C; Fobare, Sydney; Huang, Kevin M; Buelow, Daelynn R; Orwick, Shelley; Jeon, Jae Yoon; Weber, Robert H; Larsen, Bill; Mims, Alice S; Hertlein, Erin; Byrd, John C; Baker, Sharyn D.

Cancers (Basel) ; 15(1)2022 Dec 21.

Artigo em Inglês | MEDLINE | ID: mdl-36612026

17.

Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia.

Fobare, Sydney; Kohlschmidt, Jessica; Ozer, Hatice Gulcin; Mrózek, Krzysztof; Nicolet, Deedra; Mims, Alice S; Garzon, Ramiro; Blachly, James S; Orwick, Shelley; Carroll, Andrew J; Stone, Richard M; Wang, Eunice S; Kolitz, Jonathan E; Powell, Bayard L; Oakes, Christopher C; Eisfeld, Ann-Kathrin; Hertlein, Erin; Byrd, John C.

Blood Adv ; 6(5): 1371-1380, 2022 03 08.

Artigo em Inglês | MEDLINE | ID: mdl-34847232

18.

A FOXy target in B-cell survival.

Hertlein, Erin.

Blood ; 124(23): 3340-1, 2014 Nov 27.

Artigo em Inglês | MEDLINE | ID: mdl-25431475

19.

Preclinical evaluation of the Hsp90 inhibitor SNX-5422 in ibrutinib resistant CLL.

Chen, Timothy L; Harrington, Bonnie; Truxall, Jean; Wasmuth, Ronni; Prouty, Alexander; Sloan, Shelby; Lehman, Amy M; Sampath, Deepa; Orlemans, Eric; Baiocchi, Robert A; Alinari, Lapo; Byrd, John C; Woyach, Jennifer A; Hertlein, Erin.

J Hematol Oncol ; 14(1): 36, 2021 02 24.

Artigo em Inglês | MEDLINE | ID: mdl-33627156

20.

NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes.

Wang, Huating; Hertlein, Erin; Bakkar, Nadine; Sun, Hao; Acharyya, Swarnali; Wang, Jingxin; Carathers, Micheal; Davuluri, Ramana; Guttridge, Denis C.

Mol Cell Biol ; 27(12): 4374-87, 2007 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-17438126

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