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Scand J Gastroenterol ; 53(4): 471-474, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29546790

RESUMO

OBJECTIVES: The importance of case load for treatment of extrahepatic biliary atresia (BA) is debated. The aim of this study was to register results of BA treatment in a small volume centre. METHODS: Retrospective chart review study of patients with BA treated from 2000 to 2017. The institutional review board approved the study. RESULTS: Forty-five babies were identified of which 42 (93%) are alive. Forty-one patients had a Kasai portoenterostomy (PE), two had a hepaticojejunostomy and two had a primary liver transplantation. The age at PE/hepaticojejunostomy was median 63 (4-145 days). Seven surgeons performed the operations, and the median duration of the diagnostic work-up was 8 (3-24) days. Clearance of jaundice was achieved in 23/43 (53%) babies, and 3- and 5-year native liver survival was 47% and 40%, respectively. Clearance of jaundice post-PE/hepaticojejunostomy was a strong predictor of native liver survival (adjusted OR: 0.027; 95%; p = .009). Plasma level of conjugated bilirubin at time of referral was also a significant predictor of native liver survival (adjusted OR: 1.053; p = .017). CONCLUSION: A small volume centre may achieve satisfactory results for BA patients. The study has, however, identified factors that may further improve results; earlier referral, optimizing diagnostic work-up and establishing one dedicated surgical team.


Assuntos
Atresia Biliar/mortalidade , Atresia Biliar/cirurgia , Bilirrubina/sangue , Portoenterostomia Hepática/efeitos adversos , Feminino , Hospitais com Baixo Volume de Atendimentos , Humanos , Lactente , Recém-Nascido , Icterícia/etiologia , Transplante de Fígado/efeitos adversos , Masculino , Noruega/epidemiologia , Estudos Retrospectivos , Resultado do Tratamento
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