Detalhe da pesquisa
1.
In skeletal muscle and neural crest cells, SMCHD1 regulates biological pathways relevant for Bosma syndrome and facioscapulohumeral dystrophy phenotype.
Nucleic Acids Res
; 51(14): 7269-7287, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37334829
2.
GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.
J Biol Chem
; 297(2): 100928, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34274316
3.
Hydrogen Atom Transfer-Mediated Domino Cyclisation Reaction to Access (Spiro)Quinazolinones.
Chemistry
; 26(14): 3026-3029, 2020 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31922300
4.
Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'.
Bioorg Med Chem Lett
; 30(21): 127533, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32919012
5.
Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles.
Chemistry
; 24(70): 18658-18662, 2018 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30341926
6.
Atom Efficient Synthesis of Selectively Difluorinated Carbocycles through a Gold(I)-Catalyzed Cyclization.
J Org Chem
; 83(16): 8888-8905, 2018 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29978696
7.
Developing the Saegusa-Ito Cyclisation for the Synthesis of Difluorinated Cyclohexenones.
Chemistry
; 21(52): 19119-27, 2015 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26564395
8.
A modular synthesis of functionalised phenols enabled by controlled boron speciation.
Org Biomol Chem
; 13(10): 3093-102, 2015 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25628154
9.
Highly selective allylborations of aldehydes using α,α-disubstituted allylic pinacol boronic esters.
Angew Chem Int Ed Engl
; 53(24): 6145-9, 2014 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24799283
10.
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787.
J Med Chem
; 2024 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38866424
11.
Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor.
Bioorg Med Chem Lett
; 22(7): 2456-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22386243
12.
Recording the many face of death at the Denbigh Asylum, 1848-1938.
Hist Psychiatry
; 23(89 Pt 1): 40-51, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22701926
13.
In situ silane activation enables catalytic reduction of carboxylic acids.
Chem Commun (Camb)
; 58(21): 3509-3512, 2022 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35195133
14.
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
J Med Chem
; 65(22): 15174-15207, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36378954
15.
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem
; 65(3): 2262-2287, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34995458
16.
Transcriptional regulation of inducible nitric oxide synthase gene therapy: targeting early stage and advanced prostate cancer.
J Gene Med
; 12(9): 755-65, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20821746
17.
Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.
Reprod Biol Endocrinol
; 8: 22, 2010 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20210997
18.
A practical catalytic reductive amination of carboxylic acids.
Chem Sci
; 11(35): 9494-9500, 2020 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34123174
19.
A Turing Test for Molecular Generators.
J Med Chem
; 63(20): 11964-11971, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32955254
20.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
J Med Chem
; 63(2): 714-746, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904959