Detalhe da pesquisa
1.
Nigrostriatal tau pathology in parkinsonism and Parkinson's disease.
Brain
; 147(2): 444-457, 2024 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38006313
2.
Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
Proc Natl Acad Sci U S A
; 118(31)2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326260
3.
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
Proc Natl Acad Sci U S A
; 118(1)2021 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33443159
4.
Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity.
Mov Disord
; 36(12): 2719-2730, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34613624
5.
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiol Dis
; 124: 276-288, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381260
6.
G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.
J Neurosci
; 36(28): 7415-27, 2016 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27413152
7.
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.
J Biol Chem
; 291(2): 613-29, 2016 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26553875
8.
Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection.
J Neurochem
; 142(3): 429-443, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28485896
9.
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Hum Mol Genet
; 24(21): 6013-28, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26251043
10.
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.
J Biol Chem
; 290(32): 19433-44, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26078453
11.
Astrocytes Grown in Alvetex(®) Three Dimensional Scaffolds Retain a Non-reactive Phenotype.
Neurochem Res
; 41(8): 1857-67, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27099962
12.
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.
J Biol Chem
; 289(21): 14569-82, 2014 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671417
13.
Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes.
J Neurochem
; 130(5): 668-77, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24814819
14.
Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons.
J Neurochem
; 129(5): 884-94, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24494600
15.
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
J Neurochem
; 128(4): 561-76, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24117733
16.
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Bioorg Med Chem Lett
; 24(17): 4132-40, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25113930
17.
Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.
Sci Rep
; 14(1): 2061, 2024 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38267530
18.
Mixed pathology as a rule, not exception: Time to reconsider disease nosology.
Handb Clin Neurol
; 192: 57-71, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36796948
19.
ASO-mediated knockdown or kinase inhibition of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.
Mol Ther Nucleic Acids
; 34: 102064, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38028198
20.
Perspective on the current state of the LRRK2 field.
NPJ Parkinsons Dis
; 9(1): 104, 2023 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37393318