Detalhe da pesquisa
1.
Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study.
Pain Med
; 21(2): e114-e126, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31553457
2.
Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial.
Breast Cancer Res Treat
; 165(2): 329-341, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28612225
3.
Etirinotecan pegol (NKTR-102) versus treatment of physician's choice in women with advanced breast cancer previously treated with an anthracycline, a taxane, and capecitabine (BEACON): a randomised, open-label, multicentre, phase 3 trial.
Lancet Oncol
; 16(15): 1556-1568, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26482278
4.
NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer.
BMC Cancer
; 15: 685, 2015 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26463521
5.
Two schedules of etirinotecan pegol (NKTR-102) in patients with previously treated metastatic breast cancer: a randomised phase 2 study.
Lancet Oncol
; 14(12): 1216-25, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24095299
6.
Erratum to: Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial.
Breast Cancer Res Treat
; 166(1): 327-328, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28884461
7.
Treatment With Etirinotecan Pegol for Patients With Metastatic Breast Cancer and Brain Metastases: Final Results From the Phase 3 ATTAIN Randomized Clinical Trial.
JAMA Oncol
; 8(7): 1047-1052, 2022 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35552364
8.
Bempegaldesleukin plus nivolumab in first-line renal cell carcinoma: results from the PIVOT-02 study.
J Immunother Cancer
; 10(4)2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35444058
9.
Bempegaldesleukin plus Nivolumab in First-line Metastatic Urothelial Carcinoma: Results from PIVOT-02.
Eur Urol
; 82(4): 365-373, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35643589
10.
Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.
Bioorg Med Chem Lett
; 21(1): 307-10, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21109434
11.
Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma.
J Clin Oncol
; 39(26): 2914-2925, 2021 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255535
12.
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.
Bioorg Med Chem Lett
; 20(17): 5269-73, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655213
13.
NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8+ T cell responses capable of curing multi-focal cancer.
J Immunother Cancer
; 8(1)2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32457127
14.
Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02).
Cancer Discov
; 10(8): 1158-1173, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32439653
15.
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.
Nat Commun
; 11(1): 661, 2020 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32005826
16.
Metabolism of (+)-1,4-dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid (voreloxin; formerly SNS-595), a novel replication-dependent DNA-damaging agent.
Drug Metab Dispos
; 37(3): 594-601, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19074528
17.
2-Aminobenzimidazoles as potent Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 19(17): 5158-61, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19646866
18.
A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rßγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors.
Cancer Discov
; 9(6): 711-721, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30988166
19.
A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
Bioorg Med Chem Lett
; 18(21): 5763-5, 2008 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842409
20.
Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.
Bioorg Med Chem Lett
; 18(23): 6236-9, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18926699